AI Article Synopsis
- Stroke is a leading cause of death globally, and neuroinflammation and brain edema significantly heighten mortality risks after a stroke.
- Despite advancements in treating the acute phase of stroke, effective therapies for the subacute and chronic stages remain limited.
- Microglia, the immune cells in the brain, can adopt different roles during a stroke, influencing recovery outcomes, making their regulation crucial for improving stroke treatments.
Article Abstract
Stroke is one of the most common causes of death worldwide. The subsequent development of neuroinflammation and brain edema dramatically increases the risks associated with stroke, leading to a substantial increase in mortality. Although considerable progress has been made in improving cerebral perfusion in the acute phase of stroke, effective treatment options for the subacute and chronic phases associated with cerebral infarction are limited. Microglia, the innate immune cells of the central nervous system (CNS), can be activated and polarized to take on different phenotypes in response to stimulations associated with stroke, including pro-inflammatory and anti-inflammatory phenotypes, which affect the prognosis of stroke. Therefore, investigation of the activation and polarizing mechanisms of microglia plays a critical role in treating stroke. The aim of this article was to investigate the significance of microglial phenotype regulation in stroke treatment by summarizing the activation, polarizing mechanisms, and general microglia characteristics.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280287 | PMC |
| http://dx.doi.org/10.3389/fneur.2021.620948 | DOI Listing |
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