AI Article Synopsis
- - This study investigated how homocysteine (Hcy) levels relate to changes in brain structures, specifically the third ventricle (V3) and mesencephalic area (MA), in Parkinson's disease (PD) patients with cognitive impairment.
- - It included 101 PD patients and 20 controls, finding significant correlations between higher Hcy levels and wider V3 and more atrophy in MA, especially in those with cognitive issues.
- - The analysis indicated that higher Hcy levels were linked to a greater risk of both V3 dilatation and MA atrophy in PD patients, suggesting that elevated Hcy may contribute to brain degeneration in those with cognitive impairment.
Article Abstract
Objectives: This study aimed to explore the association of homocysteine (Hcy) with third ventricle (V3) dilatation and mesencephalic area (MA) atrophy as determined by transcranial sonography (TCS) in Parkinson's disease (PD) with cognitive impairment.
Methods: The final statistical analysis included 101 PD patients and 20 age- and sex-matched controls. Using the Movement Disorder Society (MDS) level II criteria for PD with cognitive impairment, we categorized the PD patients into PD with normal cognition group (PD) and PD with cognitive impairment group (PDC). All subjects underwent TCS and laboratory analysis.
Results: The V3 width (r = 0.349, P = 0.005) and the MA (r = -0.484, P < 0.001) were significantly correlated with the Hcy concentration in the PDC patients. Binary logistic regression analysis revealed that age (OR [95% CI] = 1.114 [0.991-1.251], P = 0.002), and Hcy level (OR [95% CI] = 0.931 [0.752-1.153], P = 0.411) were independent risk factors for V3 dilatation. Hcy level (OR [95% CI] = 0.557 [0.323-0.967], P = 0.035) were independent risk factors for MA atrophy. After adjustment for confounding factors, the odds ratio of V3 dilatation was 3.50 (95% CI 1.054-11.399, P = 0.031) and the odds ratio of MA atrophy was 4.67 (95% CI 1.395-15.602, P = 0.012) in the patients with higher Hcy level compared with the lower level.
Conclusions: The results revealed a close association between the V3 width, MA and Hcy concentration in PD patients with cognitive impairment. We hypothesized that increased Hcy concentration played a significant role in the development of brain atrophy in PD with cognitive impairment.
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| http://dx.doi.org/10.1016/j.jocn.2021.06.006 | DOI Listing |
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