Burn patients who survive the initial 24 h following major burn injury commonly develop a marked hypermetabolism. One of the possible mechanisms of this increased metabolic rate is gut translocation of bacteria and endotoxin following burn injury. We attempted to decrease the hypermetabolism by administering various antibiotic and endotoxin binding agents enterally in a burned guinea-pig model. Adult guinea-pigs were given polymyxin B, trimethoprim and sulphamethoxazole, or neomycin and clindamycin, or Kaopectate, sodium deoxycholate, neomycin, clindamycin and polymyxin B. A control group received no drugs. The drugs were administered through a gastrostomy tube beginning the day before burn injury and continuing for 14 days. There was no significant decrease in the resting metabolic rate in any of the treated groups compared to controls. Neither enteral antibiotics nor endotoxin binding agents were able to induce a significant reduction in the post-burn hypermetabolic response in this model.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0305-4179(87)90125-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study.
Front Endocrinol (Lausanne)
January 2025
Department of Plastic Surgery, the First Affiliated Hospital of Air Force Medical University, Xi'an, China.
Objective: Diabetic foot ulcer (DFU) is one of the common complications in patients with diabetes mellitus (DM). In order to find a method to monitor and treat the refractory DFU, the ferroptosis level in DFU and traumatic wounds (TW) was monitored and the difference between them was analyzed. At the same time, this study further analyzed the correlation of ferroptosis levels with DM severity and DFU's healing.
View Article and Find Full Text PDFType 3 deiodinase activation mediated by the Shh/Gli1 axis promotes sepsis-induced metabolic dysregulation in skeletal muscles.
Burns Trauma
January 2025
Department of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Gulou District, Nanjing, Jiangsu 210008, China.
Background: Non-thyroidal illness syndrome is commonly observed in critically ill patients, characterized by the inactivation of systemic thyroid hormones (TH), which aggravates metabolic dysfunction. Recent evidence indicates that enhanced TH inactivation is mediated by the reactivation of type 3 deiodinase (Dio3) at the tissue level, culminating in a perturbed local metabolic equilibrium. This study assessed whether targeted inhibition of Dio3 can maintain tissue metabolic homeostasis under septic conditions and explored the mechanism behind Dio3 reactivation.
View Article and Find Full Text PDFDendriform pulmonary ossification in military combat veterans: A case series.
Respir Med Case Rep
December 2024
Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO, USA.
Dendriform pulmonary ossification (DPO) is a rare condition characterized by mature bone formation in the lung. DPO has been linked to various conditions, but little is known about the link between DPO and hazardous airborne exposures. We queried research databases of military personnel evaluated for deployment-related respiratory diseases at two occupational pulmonary medicine clinics (Colorado, USA) for diagnoses of DPO, and summarized demographics, Gulf War military deployment history, medical history, and pulmonary function testing.
View Article and Find Full Text PDFPhenyl arsine oxide (PAO) is a vesicant, similar to Lewisite, a potential chemical warfare agent and an environmental contaminant. PAO-induced skin burns can trigger acute organ injury, including lungs. We have recently demonstrated that PAO burns can also has a delayed toxicity, although the specific mechanism/s remain to be determined.
View Article and Find Full Text PDFFGF-based drug discovery: advances and challenges.
Nat Rev Drug Discov
January 2025
Institute of Cell Growth Factor, Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health, Wenzhou, Zhejiang, China.
The fibroblast growth factor (FGF) family comprises 15 paracrine-acting and 3 endocrine-acting polypeptides, which govern a multitude of processes in human development, metabolism and tissue homeostasis. Therapeutic endocrine FGFs have recently advanced in clinical trials, with FGF19 and FGF21-based therapies on the cusp of approval for the treatment of primary sclerosing cholangitis and metabolic syndrome-associated steatohepatitis, respectively. By contrast, while paracrine FGFs were once thought to be promising drug candidates for wound healing, burns, tissue repair and ischaemic ailments based on their potent mitogenic and angiogenic properties, repeated failures in clinical trials have led to the widespread perception that the development of paracrine FGF-based drugs is not feasible.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!