AI Article Synopsis
- The study analyzed lamb testis cells infected with two strains of the sheeppox virus (SPPV): a wild strain (WS) and a vaccine strain (VS) during an early infection phase.
- It found that the vaccine strain (VS) led to a greater number of differentially expressed genes (DEGs) and impacted more signaling pathways than the wild strain (WS).
- The research identified key host proteins and immune-related genes that play crucial roles in viral attachment, entry, and the regulation of apoptosis, highlighting differences in the pathogenic mechanisms of the two virus strains.
Article Abstract
This study explored the transcriptome of lamb testis cells infected with sheeppox virus (SPPV) wild strain (WS) and vaccine strain (VS) at an immediate-early time. Most of the differentially expressed genes (DEGs) and differentially expressed highly connected (DEHC) gene network were found to be involved in SPPV-VS infection compared to SPPV-WS. Further, the signaling pathways were mostly involved in SPPV-VS infection than SPPV-WS. SPPV modulates the expression of several important host proteins such as CD40, FAS, ITGβ1, ITGα1, Pak1, Pak2, CD14, ILK leading to viral attachment and entry; immune-related DEGs such as MAPK, JNK, ERK, NFKB, IKB, PI3K, STAT which provide optimal cellular condition for early viral protein expression; and FOXO3, ATF, CDKNA1, TCF, SRF, BDNF which help in inducing apoptosis and MPTP, BAD and Tp53 inhibits apoptosis or cell death at the immediate-early time. The results captured the specific genes and enabled to understand distinct pathogenic mechanisms employed by VS and WS of SPPV.
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| http://dx.doi.org/10.1016/j.gene.2021.145850 | DOI Listing |
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