AI Article Synopsis
- Amanitins, found in certain mushrooms, are toxic compounds that can cause severe liver damage if consumed.
- M101 is a hemoglobin from the marine worm Arenicola marina, known for its ability to carry oxygen and also exhibit enzyme-like activity that helps break down harmful substances.
- Recent findings indicate that M101 could potentially lessen the liver damage caused by amanitins, suggesting it might be useful for medical treatment in poisoning cases.
Article Abstract
The amanitins (namely α- and β-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, are responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina. It has intrinsic Cu/Zn-SOD-like activity and is currently used as an oxygen carrier in organ preservation solutions. Our present results suggest that M101 might be effective in reducing amanitin-induced hepatotoxicity and may have potential for therapeutic development.
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| http://dx.doi.org/10.1016/j.toxicon.2021.07.004 | DOI Listing |
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