AI Article Synopsis
- - Glycans, which are sugar molecules found on the surfaces of cells, play crucial roles in how bacteria interact with their hosts, affecting both bacterial colonization and the immune responses of the host.
- - The review covers three main topics: the role of bacterial glycans in pathogenesis, the use of host glycans by bacteria, and the involvement of both in immune responses.
- - It highlights future directions for research in glycoscience, including the development of new antibacterial strategies to combat drug-resistant pathogens.
Article Abstract
Glycans are expressed on the surface of nearly all host and bacterial cells. Not surprisingly, glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host responses against pathogens. Glycan-mediated host-pathogen interactions can benefit the pathogen, host, or both. Here, we discuss (i) bacterial glycans that play a critical role in bacterial colonization and/or immune evasion, (ii) host glycans that are utilized by bacteria for pathogenesis, and (iii) bacterial and host glycans involved in immune responses against pathogens. We further discuss (iv) opportunities and challenges for transforming these research findings into more effective antibacterial strategies, and (v) technological advances in glycoscience that have helped to accelerate progress in research. These studies collectively offer valuable insights into new perspectives on antibacterial strategies that may effectively tackle the drug-resistant pathogens that are rapidly spreading globally.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758796 | PMC |
| http://dx.doi.org/10.1016/j.tim.2021.06.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!