AI Article Synopsis
- This study explored whether changes in plasma lactate levels during a 6-minute handgrip exercise test could help diagnose mitochondrial myopathy (MM), a challenging condition to identify.
- Twenty-nine MM patients and nineteen healthy controls were tested, measuring how plasma lactate levels changed during and after the exercise.
- The results showed no significant differences in lactate changes between MM patients and healthy controls, indicating that lactate levels cannot be used as a diagnostic tool for MM.
Article Abstract
Introduction/background: Mitochondrial myopathy (MM) encompasses a clinical heterogenous group of patients that can be difficult to diagnose. The aim of this study was to investigate if changes in plasma lactate concentration during a 6-minute submaximal handgrip test (6MHGT) and a 20-minute post-exercise recovery period can be used as a diagnostic test for MM.
Methods: Twenty-nine patients with MM and nineteen healthy controls (HC) performed an intermittent handgrip exercise test at ½ Hz for 6 min at 50% of maximal voluntary contraction force. We calculated the area under the curve (AUC) of change in plasma lactate during exercise and recovery and compared AUC between groups (MM vs. HC, and between MM subgroups based on disease severity).
Results: The change in plasma lactate during exercise and recovery was similar in MM and HC (p = 0.65 and p = 0.57) and similar between MM subgroups (p ≥ 0.24).
Conclusion: Plasma lactate measured during and after a submaximal 6MHGT cannot be used as a diagnostic variable for MM.
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| http://dx.doi.org/10.1016/j.mito.2021.07.002 | DOI Listing |
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