A number of carbobenzoxy-dipeptide-amides raise the bilayer to hexagonal phase transition temperature of dielaidoylphosphatidylethanolamine (stabilizes the bilayer). The potency of the peptides in stabilizing the bilayer phase is Z-Tyr-Leu-NH2 = Z-Gly-Phe-NH2 greater than Z-Ser-Leu-NH2 greater than Z-Gly-Leu-NH2 greater than Z-Gly-Gly-NH2. A linear correlation was found between the respective HPLC retention time parameter k' for the peptide and the slope of the bilayer stabilization curve determined with model membranes by differential scanning calorimetry. One dipeptide, Z-Ser-Leu-NH2, reduces measles virus cytopathic effect (CPE) in Vero cells. The mechanism by which this peptide reduces the CPE is not known, although some peptides which raise the bilayer to hexagonal phase transition temperature of phospholipids inhibit membrane fusion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF01116868 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Lipid Headgroups on the Mechanical Properties and In Vitro Cellular Internalization of Liposomes.
Langmuir
January 2025
Department of Chemical Engineering, Northeastern University, Boston, Massachusetts 02115, United States.
We performed all-atom and coarse-grained simulations of lipid bilayer mixtures of the unsaturated lipid DOPC, with saturated lipids having the same 18-carbon acyl tails and different headgroups, to understand their mechanical properties. The secondary lipids were DSPG, DSPA, DSPS, DSPC, and DSPE. The DOPC:DSPG system with 65:35 molar ratio was the softest, with area compressibility modulus ∼ 22% smaller than the pure DOPC value.
View Article and Find Full Text PDFGlassy Dynamics and Local Crystalline Order in Two-Dimensional Amorphous Silica.
J Phys Chem B
January 2025
Dipartimento di Fisica, Università di Trieste, Strada Costiera 11, 34151 Trieste, Italy.
We reassess the modeling of amorphous silica bilayers as a 2D classical system whose particles interact with an effective pairwise potential. We show that it is possible to reparametrize the potential developed by Roy, Heyde, and Heuer to quantitatively match the structural details of the experimental samples. We then study the glassy dynamics of the reparametrized model at low temperatures.
View Article and Find Full Text PDFCrystallographic insights into lipid-membrane protein interactions in microbial rhodopsins.
Front Mol Biosci
November 2024
Institut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes-CEA-CNRS, Grenoble, France.
The primary goal of our work is to provide structural insights into the influence of the hydrophobic lipid environment on the membrane proteins (MPs) structure and function. Our work will not cover the well-studied hydrophobic mismatch between the lipid bilayer and MPs. Instead, we will focus on the less-studied direct molecular interactions of lipids with the hydrophobic surfaces of MPs.
View Article and Find Full Text PDFThe imaging performance of extreme ultraviolet (EUV) lithography is determined by the optical properties and thickness of the photomask absorber material and the illumination source shape. Optimizing the trade-offs between imaging metrics, such as normalized image log slope, telecentricity error, and best focus variation through pitch (collectively known as mask-3-dimensional (M3D) effects), is crucial to improve the throughput of the EUV lithography process. This study aims to optimize Ru/Ta bilayer photomask absorber stacks and illumination source shapes to mitigate M3D effects using mask diffraction analysis.
View Article and Find Full Text PDFTwenty Years of Graphene: From Pristine to Chemically Engineered Nano-Sized Flakes.
J Am Chem Soc
November 2024
Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, 28040 Madrid, Spain.
It is a celebratory moment for graphene! This year marks the 20th anniversary of the discovery of this amazing material by Geim and Novoselov. Curiously, it coincides with the century mark of graphite's layered structure discovery. Since the discovery of graphene with the promise that its outstanding properties would change the world, society often wonders where is graphene? In this context, their discoverers said in 2005, "despite the reigning optimism about graphene-based electronics, "graphenium" microprocessors are unlikely to appear for the next 20 years".
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!