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Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia.
Pharmacol Res
January 2025
Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria. Electronic address:
Our understanding of how sex and age influence chronic pain at the molecular level is still limited with wide-reaching consequences for adolescent patients. Here, we leveraged deep proteome profiling of mouse dorsal root ganglia (DRG) from adolescent (4-week-old) and adult (12-week-old) male and female mice to investigate the establishment of neuropathic pain in the spared nerve injury (SNI)-model in parallel. We quantified over 12,000 proteins, including notable ion channels involved in pain, highlighting the sensitivity of our approach.
View Article and Find Full Text PDFComparative Study Between the Analgesic Effect of Prednisolone and Pregabalin in Managing Post Dural Puncture Headache After Lower Limb Surgeries.
Pain Physician
December 2024
Departments of Anesthesia, Intensive Care, and Pain Management, Faculty of Human Medicine, Zagazig University Alsharkia, Egypt.
Background: Post dural puncture headache (PDPH) is a major challenging complication and may be a cause of morbidity after spinal anesthesia. Currently there is no definitive management for PDPH, so the search for effective treatment continues.
Objectives: Our aim was to investigate the analgesic effectiveness of oral prednisolone vs oral pregabalin for managing PDPH subsequent to spinal anesthesia for lower limb surgeries.
Evaluating pain management practices for cancer patients among health professionals in cancer and supportive/palliative care units: a Belgian survey.
Support Care Cancer
November 2024
Department of Medical Oncology, Institut Jules Bordet, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Background: Pain is reported in 66% of cancer patients with advanced disease. Adequate pain management is a cornerstone of comprehensive supportive cancer care.
Purpose: The purpose of this study was to assess pain management in Oncology Units in Belgium.
Recognizing serotonin syndrome in the intensive care unit: a case report of serotonin syndrome in a patient taking amitriptyline, buprenorphine, pregabalin, and fentanyl.
AME Case Rep
August 2024
Department of Pulmonary and Critical Care Medicine, St. Joseph's University Medical Center, Paterson, NJ, USA.
Background: Despite its life-threatening nature, serotonin syndrome (SS) often eludes initial recognition and remains an underreported condition that can occur with the administration of serotonergic drugs alone or in combination with other medications known to increase levels of serotonin. The diagnosis of SS relies on clinical assessment, as laboratory tests and imaging studies cannot definitively confirm the condition. The majority of reported cases of SS involve polypharmacy rather than single-drug overdose.
View Article and Find Full Text PDFEfficacy of nonopioid analgesics and adjuvants in multimodal analgesia for reducing postoperative opioid consumption and complications in obesity: a systematic review and network meta-analysis.
Br J Anaesth
December 2024
Department of Medicine - DIMED, Section of Anaesthesiology and Intensive Care, University of Padova, Padova, Italy; Institute of Anaesthesia and Intensive Care, Padua University Hospital, Padova, Italy.
Article Synopsis
- Managing postoperative pain for patients with obesity is complicated, and this study explores the effectiveness of various nonopioid intravenous analgesics and adjuvants in reducing opioid use and recovery complications after surgery.
- A systematic review of 37 randomized controlled trials found that medications like dexmedetomidine, ketamine, lidocaine, and gabapentin significantly decreased opioid consumption and postoperative issues such as nausea and vomiting in these patients.
- The findings suggest that these nonopioid analgesics are vital in improving postoperative care, ultimately leading to better outcomes for obese patients undergoing surgery.
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