We study the diffusive transport of Markovian random walks on arbitrary networks with stochastic resetting to multiple nodes. We deduce analytical expressions for the stationary occupation probability and for the mean and global first passage times. This general approach allows us to characterize the effect of resetting on the capacity of random walk strategies to reach a particular target or to explore the network. Our formalism holds for ergodic random walks and can be implemented from the spectral properties of the random walk without resetting, providing a tool to analyze the efficiency of search strategies with resetting to multiple nodes. We apply the methods developed here to the dynamics with two reset nodes and derive analytical results for normal random walks and Lévy flights on rings. We also explore the effect of resetting to multiple nodes on a comb graph, Lévy flights that visit specific locations in a continuous space, and the Google random walk strategy on regular networks.
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http://dx.doi.org/10.1103/PhysRevE.103.062126 | DOI Listing |
J Neuroimmunol
December 2024
Versiti Blood Research Institute, Milwaukee, WI, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:
Curr Opin Neurobiol
December 2024
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Brain Immunology and Glia Center, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:
Critical periods are brief windows of heightened neural circuit plasticity that allow circuits to permanently reset their structure and function to facilitate robust organismal behavior. Understanding the cellular and molecular mechanisms that instruct critical period timing is of broad clinical interest, as altered developmental plasticity is linked to multiple neurodevelopmental disorders. While intrinsic, neuronal mechanisms shape both neural circuit remodeling and critical period timing, recent data indicate that signaling from astrocytes and surrounding glia can both promote and limit critical period plasticity.
View Article and Find Full Text PDFJ Neuroimmunol
December 2024
Versiti Blood Research Institute, Milwaukee, WI, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:
In multiple sclerosis (MS) the B cell depleting drug ocrelizumab has shown high efficacy in reducing inflammatory activity. Its mechanism of action is unclear due to B cell subset complexity and unknown roles in pathogenesis. Here, we comprehensively phenotyped and quantitated peripheral blood B cell subsets before and after ocrelizumab infusion to gain insight into the fate of B cell subsets with pathogenic potential.
View Article and Find Full Text PDFMol Biol Cell
January 2025
Division of Biology and Chemistry, Paul Scherrer Institut, Villigen 5232, Switzerland.
Aging is associated with a progressive decline in cellular function. To reset the aged cellular phenotype, various reprogramming approaches, including mechanical routes, have been explored. However, the epigenetic mechanisms underlying cellular rejuvenation are poorly understood.
View Article and Find Full Text PDFOmega (Westport)
November 2024
School of Psychology and Vision Sciences, University of Leicester, Leicester, UK.
Home care workers (HCWs) may frequently experience client death. This critical interpretive meta-synthesis aimed to identify the impacts of client death to offer preliminary recommendations with respect to support. Five electronic databases, APA PsycINFO, CINAHL, MEDLINE, Web of Science, and Scopus, were searched systematically using keywords and subject headings.
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