AI Article Synopsis
- PCSK9 has significant roles not only in lipid metabolism and cardiovascular risk but also in innate immunity and the pathogenesis of various viral and bacterial infections.
- Evidence suggests PCSK9 is involved in diseases like HCV, sepsis, malaria, and potentially in protecting against infections like dengue and SARS-CoV-2.
- Ongoing research highlights the potential benefits of PCSK9 inhibition in treating HIV-related hyperlipidemia, reducing HCV replication, and improving outcomes in malaria and sepsis.
Article Abstract
Background: In recent years, many aspects of the physiological role of PCSK9 have been elucidated, in particular regarding its role in lipid metabolism, cardiovascular risk but also its role in innate immunity. Increasing evidence is available on the involvement of PCSK9 in the pathogenesis of viral infections, mainly HCV, as well as in the regulation of host response to bacterial infections, mainly sepsis and septic shock. Moreover, the action of PCSK9 has been investigated as a crucial step in the pathogenesis of malaria infection and disease severity.
Objective: Aim of this paper is to review available published literature on the role of PCSK9 in a wide array of infectious diseases.
Conclusion: Besides the ongoing investigation on PCSK9 inhibition among HIV-infected patients for the treatment of HIV- and ART-related hyperlipidemia, preclinical studies indicate how PCSK9 is involved in reducing the replication of HCV. Moreover, a protective role of PCSK9 inhibition has also been proposed against dengue and SARS-CoV-2 viral infections. Interestingly, high plasmatic PCSK9 levels have been described in patients with sepsis. Finally, a loss of function in the PCSK9-encoding gene has been reported to possibly reduce mortality in malaria infection.
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| http://dx.doi.org/10.2174/0929867328666210714160343 | DOI Listing |
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