Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446992 | PMC |
| http://dx.doi.org/10.1111/trf.16452 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy and safety of a 72-h infusion of prostacyclin (1 ng/kg/min) in mechanically ventilated patients with pulmonary infection and endotheliopathy-protocol for the multicenter randomized, placebo-controlled, blinded, investigator-initiated COMBAT-ARF trial.
Acta Anaesthesiol Scand
January 2025
CAG Center for Endotheliomics, Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Background: Acute respiratory failure (ARF) is common in critically ill patients, and 50% of patients in intensive care units require mechanical ventilation [3, 4]. The COVID-19 pandemic revealed that COVID-19 infection induced ARF caused by damage to the microvascular pulmonary endothelium. In a randomized clinical trial, mechanically ventilated COVID-19 patients with severe endotheliopathy, as defined by soluble thrombomodulin (sTM) ≥ 4 ng/mL, were randomized to evaluate the effect of a 72-h infusion of low-dose prostacyclin 1 ng/kg/min or placebo.
View Article and Find Full Text PDFElevation of NT-proBNP Levels in Pediatric and Young Adult Hematopoietic Stem Cell Transplant Patients with Endotheliopathy.
Pediatr Rep
October 2024
Division of Pediatric Critical Care Medicine, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 734 Room IA3309, Memphis, TN 38105, USA.
Background/objectives: Hematopoietic stem cell transplantation (HSCT) in pediatric and young adult (YA) patients can lead to endotheliopathy, such as thrombotic microangiopathy (TMA), sinusoidal obstruction syndrome (SOS), and diffuse alveolar hemorrhage (DAH). Natriuretic peptides have been studied as markers of endotheliopathy and critical illness. We hypothesized that an elevation in NT-proBNP was associated with the development of endotheliopathy (DAH, SOS, or TMA) in the first 100 days following HSCT in pediatric and YA patients.
View Article and Find Full Text PDFPlasmas From Patients With Burn Injury Induce Endotheliopathy Through Different Pathways.
J Surg Res
December 2024
The Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, District of Columbia; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia; Departments of Surgery and Biochemistry, Georgetown University School of Medicine, Washington, District of Columbia. Electronic address:
Introduction: The contribution of endothelial injury to the pathogenesis of burn shock is not well characterized. This work investigates potential mechanisms underlying dysregulation of endothelial barrier function by burn patient plasmas.
Methods: Plasma was collected from burn-injured patients (n = 8) within 4 h of admission.
The benefits of prophylactic defibrotide: Are the tides turning?
Pediatr Blood Cancer
January 2025
Pediatric Hematology Oncology and Stem Cell Transplant, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Article Synopsis
- - Veno-occlusive disease (VOD) is a serious condition that can arise after stem cell transplants (SCT), with various factors influencing its development, and the effectiveness of prophylactic defibrotide (DF) is still being evaluated.
- - The study examined 58 pediatric SCT patients to compare VOD incidence, severity, and survival outcomes between those who received prophylactic DF and those who did not.
- - While results weren't statistically significant, patients who developed VOD after not receiving prophylactic DF had worse disease severity and lower one-year survival rates compared to those who received DF.
Phenotyping vestibulocochlear manifestations in Susac syndrome: a cohort study.
Eur Arch Otorhinolaryngol
October 2024
Department of Otorhinolaryngology, Department of Head and Skin, Ghent University Hospital, Ghent, Belgium.
Article Synopsis
- The study aims to understand how the vestibulocochlear system is affected in patients with Susac syndrome (SuS), which is a rare condition that impacts the brain, eyes, and inner ear.
- A review of 21 patient files shows that most experienced various audiovestibular symptoms, including vertigo and sensorineural hearing loss, with specific audiological and vestibular testing revealing common patterns of dysfunction.
- The findings suggest that early treatment with immunosuppressive therapy can help prevent severe audiovestibular problems, indicating the need for more research to understand the underlying causes and improve patient outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!