Purpose: The purpose of this study was to explore the curative effect and safety of hyperfractionated accelerated radiotherapy (HART) and conventional fractionated radiotherapy (CFRT) combined with EP chemotherapy regimen in the treatment of limited-stage small cell lung cancer (LS-SCLC).
Methods: A total of 148 patients with LS-SCLC were retrospectively analyzed. 74 cases underwent HART combined with EP chemotherapy regimen (HART group), while the remaining 74 cases underwent CFRT combined with EP chemotherapy regimen (Control group). The short-term response rate and quality-of-life score were compared between the two groups. Then the patients were followed up, and the survival status of them was recorded.
Results: The curative effect was evaluated in all patients at 2 months after treatment. The overall response rate was 86.5% and 68.9%, respectively, in HART group and Control group. After treatment, the scores of physical function, role function, cognitive function, emotional function, social function and general health status were all higher in HART group than those in Control group. In HART group, the score of nausea/vomiting was significantly higher than that in Control group. The median overall survival (OS) was 23.6 months and 20.2 months, and the 3-year OS rate was 21.6% and 14.9%, respectively, in HART group and Control group. The results of log-rank test revealed that the OS rate had a statistically significant difference between the two groups, and it was remarkably superior in HART group to that in Control group.
Conclusions: HART combined with EP chemotherapy regimen has a better curative effect on LS-SCLC than conventional radiotherapy, and the survival rate of patients is higher, without significantly increasing adverse reactions and significantly reducing quality of life, so it is worthy of clinical popularization.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Influence of Sex and Body Composition on Aerobic Capacity in Normal Weight Lean, Normal Weight Obese, and Obese Phenotypes.
Int J Environ Res Public Health
January 2025
Department of Nutrition and Health Science, Ball State University, Muncie, IN 47306, USA.
Normal weight obesity (NWO) is a body composition phenotype that is associated with increased cardiometabolic risk and is characterized by a normal weight body mass index but elevated body fat. The purpose of this study was to determine sex differences in aerobic capacity across body composition phenotypes, including normal weight lean (NWL), NWO, and traditional obesity (OB). We recruited 60 participants according to three body composition phenotypes: NWL (n = 10 females, n = 10 males), NWO (n = 10 females, n = 10 males), and OB (n = 10 females, n = 10 males).
View Article and Find Full Text PDFSeroprevalence of Borrelia burgdorferi sensu lato antibodies in English adult blood donors: A nationwide cross-sectional study, 2021-2022.
Ticks Tick Borne Dis
January 2025
National Institute for Health and Social Care Research Health Protection Research Unit in Emerging and Zoonotic Infections, UK; Rare and Imported Pathogens Laboratory, UK Health Security Agency, Porton Down, UK. Electronic address:
Background: Estimates of Lyme disease incidence in England are based on reporting of cases with a laboratory-confirmed diagnosis only, underestimating total cases. In 2017 - 2018, two independent reviews commissioned by the UK Government highlighted the lack of official data on Lyme disease prevalence and incidence as a critical knowledge gap.
Aim: To estimate the prevalence of IgG antibodies in the English adult population specific for Borrelia burgdorferi sensu lato (Bbsl), the causative agent of Lyme disease.
The MASCC COG-IMPACT: An unmet needs assessment for cancer-related cognitive impairment impact developed by the Multinational Association of Supportive Care in Cancer.
Support Care Cancer
January 2025
Human Performance Research Centre, INSIGHT Research Institute, Faculty of Health, University of Technology Sydney (UTS), Moore Park, Sydney, NSW, 2030, Australia.
Purpose: Cancer-related cognitive impairment (CRCI) can have a profound impact on the lives of cancer survivors. A multitude of subjective and objective assessment tools exist to assess the presence and severity of CRCI. However, no purpose-built tool exists to assess the unmet needs of cancer survivors directly relating to CRCI.
View Article and Find Full Text PDFContent Validity of a New Soccer (Football) Return-to-Play Test: The RONDO-TEST.
J Funct Morphol Kinesiol
December 2024
Institut Nacional d'Educació Física de Catalunya (INEFC), Partida la Caparrella, 97, E-25192 Lleida, Spain.
Objectives: The aim was to assess the content validity of a new field test on general and soccer-specific motor skills before return to play.
Methods: The RONDO-TEST was assessed by a Delphi panel for its content validity. It included a survey to evaluate 16 items related to the test consisting of four 10 m lines which cross over at their mid-point, resulting in eight 5 m sectors that include locomotor skills (speeding, moving sideways, side cutting, and jumping) and soccer-specific technical skills (dribbling, slalom course, and kicking/passing).
Sex Differences in Long COVID.
JAMA Netw Open
January 2025
University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Importance: A substantial number of individuals worldwide experience long COVID, or post-COVID condition. Other postviral and autoimmune conditions have a female predominance, but whether the same is true for long COVID, especially within different subgroups, is uncertain.
Objective: To evaluate sex differences in the risk of developing long COVID among adults with SARS-CoV-2 infection.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!