AI Article Synopsis
- The gut is crucial in understanding sepsis, a severe condition resulting from an unregulated immune response to infection, especially in ICU patients.
- Probiotics show mixed results in sepsis: they can help improve inflammation and reduce severity in some cases, but may also worsen sepsis and mortality in others, especially in certain populations.
- This review examines various studies to explore both the positive and negative impacts of probiotic therapy on sepsis treatment.
Article Abstract
For decades, the gut has been thought to play an important role in sepsis pathogenesis. Sepsis is a serious life-threatening, chronic condition of an infection caused by dysregulated host immune response in most of the intensive care unit patients. Probiotics have dual roles in polymicrobial sepsis i.e. probiotics may induce sepsis in many cases and may prevent its prognosis in many cases. Experimental evidence from both pre-clinical and clinical studies have demonstrated that probiotic therapy ameliorates various inflammatory mediators such as tumor necrosis factor, interleukin-10 (IL-10), IL-6, etc., in septicemia. In addition, probiotic use was also found to reduce the severity of pathological conditions associated with irritable bowel disorder and prevent development of endocarditis in septicemia. On contrary, probiotic therapy in neonatal and athymic adult mice fail to provide any beneficial effects on mortality and sepsis-induced inflammation. Importantly, in few clinical trials probiotic use was found to aggravate sepsis by promoting inflammatory cascade rather than suppressing it. This review discusses various studies regarding the beneficial or harmful effects associated with probiotic therapy in sepsis.
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| http://dx.doi.org/10.1007/s11655-021-3334-5 | DOI Listing |
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