Unlabelled: Long-term environmental air pollution exposure was associated with osteoporosis' risk in a cohort of women at high risk of fracture. Cortical sites seemed to be more susceptible to the exposure's effect.
Introduction: Environmental air pollution has been associated with disruption of bone health at a molecular level. Particulate matter (PM) exposure can simultaneously stimulate bone resorption and halt bone formation. The primary aim of the present study is to describe the association between long-term exposure to PM and osteoporosis in a large cohort of women at high risk of fracture.
Methods: Clinical, demographic, and densitometric data were extracted from the DeFRAcalc79 dataset, which gathers data on women at risk for osteoporosis. Data on the monitoring of PM10 and PM2.5 concentrations were retrieved from the Italian institute of environment protection and research (Istituto Superiore per la Protezione e la Ricerca Ambientale, ISPRA). Generalized linear models with robust estimators were employed to determine the relationship between BMD and PM long-term exposure.
Results: A total 59,950 women from 110 Italian provinces were included in the study. PM 2.5 exposure was negatively associated with T-score levels at the femoral neck (β -0.005, 95 CI -0.007 to -0.003) and lumbar spine (β -0.003, 95% CI -0.006 to -0.001). Chronic exposure to PM2.5 above 25 μg/m was associated with a 16% higher risk of having osteoporotic T-score at any site (aOR 1.161, 95% CI 1.105 to 1.220), and exposure to PM10 above 30 μg/m was associated with a 15% higher risk of having osteoporotic T-score at any site (aOR 1.148, 95% CI 1.098 to 1.200).
Conclusion: Long-term exposure to air pollution was associated with higher risk of osteoporosis. Femoral neck site seemed to be more susceptible to the detrimental effect of PM exposure than lumbar spine site.
Key Message: Exposure to air pollution is associated with osteoporosis, mainly at femoral site.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758604 | PMC |
| http://dx.doi.org/10.1007/s00198-021-06060-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Do meteorological variables impact air quality differently across urbanization gradients? A case study of Kaohsiung, Taiwan, China.
Heliyon
January 2025
School of Architecture, Tianjin University, 300072, Tianjin, China.
Air pollution has become a major challenge to global urban sustainable development, necessitating urgent solutions. Meteorological variables are key determinants of air quality; however, research on their impact across different urban gradients remains limited, and their mechanisms are largely unexplored. This study investigates the dynamic effects of meteorological variables on air quality under varying levels of urbanization using Kaohsiung City, Taiwan, as a case study.
View Article and Find Full Text PDFOccupational Exposure to Air Pollutants and Higher Risk of COPD in Construction Workers: A Meta-Analysis Study.
Indian J Occup Environ Med
December 2024
Department of Electronics, Sri Venkateswara College, University of Delhi, New Delhi, India.
Introduction: Construction sites generate high levels of air pollution, contributing to more than 4% of particulate matter in the atmosphere. Literature indicates that on-site pollution is an important factor that contributes to lung impairments in construction workers. Chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ADRS) are known to be exacerbated because of exposure to a variety of construction pollutants mainly particulate matter (PM10, PM2.
View Article and Find Full Text PDFThe association between short-term exposure to ambient PM and hospitalization costs in patients with myocardial infarction: a hospital-based study.
Int J Environ Health Res
January 2025
School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
Myocardial infarction (MI) ranks as one of the primary causes of global disabilities and disease deaths. The association between fine particulate matter (PM2.5) and MI has gained attention in recent years.
View Article and Find Full Text PDFResidential Exposure to PM Constituents and Fecundability in a Danish Preconception Cohort.
Paediatr Perinat Epidemiol
January 2025
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Background: Epidemiologic studies have demonstrated that ambient concentrations of particulate matter < 2.5 μm (PM) are associated with reduced fecundability, the per cycle probability of conception. The specific constituents driving this association are unknown.
View Article and Find Full Text PDFInterest in carbon dioxide (CO) sensors is growing rapidly due to the increasing awareness of the link between air quality and health. Indoor, high CO levels signal poor ventilation, and outdoor the burning of fossil fuels and its associated pollution. CO gas sensors based on integrated optical waveguides are a promising solution due to their excellent gas sensing selectivity, compact size, and potential for mass manufacturing large volumes at low cost.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!