Introduction: Cardiorespiratory fitness (CRF) may mitigate Alzheimer's disease (AD) progression. This study examined the longitudinal associations of CRF with brain atrophy and cognitive decline in a late-middle-aged cohort of adults at risk for AD.
Methods: One hundred ten cognitively unimpaired adults (66% female, mean age at baseline 64.2 ± 5.7 years) completed a baseline graded treadmill exercise test, two brain magnetic resonance imaging scans (over 4.67 ± 1.17 years), and two to three cognitive assessments (over 3.26 ± 1.02 years). Linear mixed effects models examined the longitudinal associations adjusted for covariates.
Results: Participants with higher baseline CRF had slower annual decline in total gray matter volume (= .013) and cognitive function (= .048), but not hippocampal volume (= .426). Exploratory analyses suggested these effects may be stronger among apolipoprotein E ε4 carriers.
Discussion: CRF is a modifiable physiological attribute that may be targeted during the preclinical phase of AD in effort to delay disease progression, perhaps most effectively among those with genetic risk.
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| http://dx.doi.org/10.1002/dad2.12212 | DOI Listing |
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