Background: Chemotherapy resistance is an intractable problem in treating patients with epithelial ovarian cancer (EOC). Heat shock proteins (HSPs) act as apoptosis inhibitors and are highly conserved genetically. Most HSPs have strong cytoprotective effects, and their overexpression inhibits apoptosis. This has been demonstrated for . Heat shock protein 70 () expression is abnormally upregulated in malignant cells. Furthermore, can inhibit cell death and promote chemotherapeutic resistance. In our study, the relationship between the gene and primary chemotherapy resistance and clinical outcome in patients with EOC was explored.
Methods: Quantitative real-time polymerase chain (qRT-PCR) was applied to determine messenger RNA (mRNA) levels, and immunohistochemistry assay was conducted to determine protein level. overexpression was assessed to clarify its role on chemotherapy resistance to cisplatin in SKOV3 cell lines.
Results: RT-qPCR assay indicated a strong relationship between expression and chemotherapy resistance in patients with EOC. In cultured SKOV3 cells, overexpression of inhibited cell sensitivity to cisplatin. Kaplan-Meier analysis demonstrated high expression was associated with poor outcome of EOC patients. In multivariate models, high expression independently predicted this poor outcome.
Conclusions: predicts the prognosis and response to chemotherapy in EOC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246186 | PMC |
| http://dx.doi.org/10.21037/atm-21-2087 | DOI Listing |
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