Pregnant Long-Evans rats were fed a liquid diet containing ethanol during gestation (peak blood ethanol level of 128 mg/dl). Pairfed dams were given isocaloric diet lacking ethanol; and control dams were allowed ad libitum access to liquid diet without ethanol. Subsequent effects of ethanol were measured by morphometric analysis of electron micrographs. Tissue samples from the molecular layer of the cerebellum (sixth lobule) were stained with ethanolic-phosphotungstic acid (E-PTA) and synaptic junctions were counted. Numbers of synaptic junctions per unit area were compared for 14 and 28 day old offspring of ethanol treated, pairfed or control dams. Synaptic density of the molecular layer of the sixth cerebellar lobule was decreased in 28 day old animals which were exposed prenatally to ethanol.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Emotional stress increases GluA2 expression and potentiates fear memory via adenylyl cyclase 5.
Cell Rep
January 2025
Department of Cell Biology and Anatomy, LSUHSC, New Orleans, LA 70112, USA; Southeast Louisiana VA Healthcare System, New Orleans, LA 70119, USA. Electronic address:
Stress can alter behavior and contributes to psychiatric disorders by regulating the expression of the GluA2 AMPA receptor subunit. We have previously shown in mice that exposure to predator odor stress elevates GluA2 transcription in cerebellar molecular layer interneurons (MLIs), and MLI activity is required for fear memory consolidation. Here, we identified the critical involvement of adenylyl cyclase 5, in both the stress-induced increase in GluA2 in MLIs and the enhancement of fear memory.
View Article and Find Full Text PDFSimulation of the biocide distribution in soil using PELMO coupled with COMLEAM.
Environ Sci Pollut Res Int
January 2025
Institute for Bioanalysis, University of Applied Sciences Coburg, Coburg, Germany.
Biocides, applied in building materials as antimicrobial protectants, can be leached out by rain, presenting substantial environmental risks as confirmed by studies on aquatic environments. However, these biocides are consistently released throughout the year in a diluted form, posing unique challenges for the prediction of transport, transformation, and ecotoxicity assessment in soil. To address this challenge, we combined COMLEAM, which predicts leaching from facades into the soil, with the FOCUS PELMO pesticide model to predict biocide distribution in soil.
View Article and Find Full Text PDFA molecularly imprinted ratio fluorescence sensor based on metal-enhanced fluorescence of core-shell structure CaF-silver nanoparticle for visual detection of dicamba.
Anal Bioanal Chem
January 2025
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Although fluorescence analysis methods are widely used in pesticide residue detection, improving their sensitivity and selectivity remains a challenge. This paper presents a novel ratio fluorescence sensor based on the molecular imprinting polymers (MIPs) and metal-enhanced fluorescence for visual detection of dicamba (DIC). Calcium fluoride (CaF) quantum dots (QDs) were immobilized on the surface of Ag@MIPs, resulting in a blue fluorescence response signal (Ag@MIPs-CaF).
View Article and Find Full Text PDFLong-Life Zinc Anodes via Molecular-Layer-Deposited Inorganic-Organic Hybrid Titanicone Thin Films.
ACS Appl Mater Interfaces
January 2025
National Laboratory of Solid-State Microstructure, College of Engineering and Applied Sciences, Collaborative Innovation Center of Advanced Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing 210093, P. R. China.
Zinc-ion batteries (ZIBs) have consistently faced challenges related to the instability of the zinc anode. Uncontrolled dendrite growth, hydrogen evolution reaction (HER), and byproduct accumulation on the zinc anode severely affect the cycling life of ZIBs. Herein, inorganic-organic hybrid thin films of titanicones (Ti-based hydroquinone, TiHQ) were fabricated by molecular layer deposition (MLD) technology to modify the zinc metal anode.
View Article and Find Full Text PDFBackground: The TAR DNA-binding protein of 43 kDa (TDP-43) is linked to hippocampal volume loss and faster rates of hippocampal atrophy in Alzheimer's disease and primary age-related tauopathy (PART). Hence, TDP-43 is becoming an important player in age-related neurodegeneration. To advance our understanding of TDP-43 effect on hippocampus, we conducted an imaging-pathological study to determine which specific hippocampal subfields are affected by TDP-43 in cases of PART.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!