[ infection and its susceptibility factors in children with inflammatory bowel disease].

Objective: To investigate the incidence rates of colonization and infection (CDI) in children with inflammatory bowel disease (IBD) and the susceptibility factors for CDI in children with IBD.

Methods: A total of 62 children diagnosed with IBD were enrolled as the IBD group. Forty-two children who attended the hospital due to persistent or chronic diarrhea and were excluded from IBD were enrolled as the non-IBD group. The incidence rate of CDI was compared between the two groups. According to the presence or absence of CDI, the IBD group was subdivided into two groups:IBD+CDI (=12) and non-CDI IBD (=50), and the clinical data were collected from the two groups to analyze the susceptibility factors for CDI.

Results: The IBD group had a significantly higher incidence rate of CDI[19% (12/62) vs 2% (1/42); < 0.05] than the non-IBD group ( < 0.05). Compared with the non-CDI IBD group, the IBD+CDI group had a significantly longer disease course ( < 0.05), and a significantly higher proportion of children with fever, diarrhea, or abdominal pain ( < 0.05). The IBD+CDI group had significantly higher activity indices of pediatric Crohn's disease, C-reactive protein levels and erythrocyte sedimentation rate than the non-CDI IBD group ( < 0.05). The univariate analysis showed that compared with the non-CDI IBD group, the IBD+CDI group had a significantly higher proportion of children with moderate-to-severe disease, use of glucocorticoids, or treatment with broad-spectrum antibiotics for more than 14 days before diagnosis ( < 0.05).

Conclusions: The children with IBD have a higher incidence of CDI than those without IBD. Severe disease conditions and use of broad-spectrum antibiotics or glucocorticoids may be associated with an increased incidence of CDI in children with IBD.