A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Does Gender Matter: A Multi-Institutional Analysis of Viscoelastic Profiles for 1565 Trauma Patients With Severe Hemorrhage. | LitMetric

AI Article Synopsis

  • The study investigates how gender differences in viscoelastic tests (TEG and ROTEM) affect survival rates in trauma patients experiencing severe hemorrhage, with the backdrop of previous findings that female patients may have a survival advantage due to hypercoagulability.
  • A retrospective analysis of 1,565 trauma patients showed that females had distinct clotting characteristics compared to males, including longer reaction times and higher clot strength, but ultimately no significant differences in in-hospital mortality were observed for either gender.
  • The authors conclude that while there are notable gender-based differences in clotting parameters, these do not correlate with differences in survival rates, highlighting the need for further research through prospective studies.

Article Abstract

Background: Viscoelastic tests including thromboelastography (TEG) and rotational thromboelastometry (ROTEM) are being used in patients with severe hemorrhage at trauma centers to guide resuscitation. Several recent studies demonstrated hypercoagulability in female trauma patients that was associated with a survival advantage. The objective of our study was to elucidate the effects of gender differences in TEG/ROTEM values on survival in trauma patients with severe hemorrhage.

Methods: A retrospective review of consecutive adult patients receiving massive transfusion protocol (MTP) at 7 Level I trauma centers was performed from 2013 to 2018. Data were stratified by gender and then further examined by TEG or ROTEM parameters. Results were analyzed using univariate and multi-variate analyses.

Results: A total of 1565 patients were included with 70.9% male gender (n = 1110/1565). Female trauma patients were older than male patients (43.5 ± .9 vs 41.1 ± .6 years, = .01). On TEG, females had longer reaction times (6.1 ± .9 min vs 4.8 ± .2 min, = .03), increased alpha angle (68.6 ± .8 vs 65.7 ± .4, < .001), and higher maximum amplitude (59.8 ± .8 vs 56.3 ± .4, < .001). On ROTEM, females had significantly longer clot time (99.2 ± 13.7 vs 75.1 ± 2.6 sec, = .09) and clot formation time (153.6 ± 10.6 sec vs 106.9 ± 3.8 sec, < .001). When comparing by gender, no difference for in-hospital mortality was found for patients in the TEG or ROTEM group ( > .05). Multivariate analysis showed no survival difference for female patients (OR 1.11, 95% CI .83-1.50, = .48).

Conclusions: Although a difference between male and females was found on TEG/ROTEM for certain clotting parameters, no difference in mortality was observed. Prospective multi-institutional studies are needed.

Download full-text PDF

Source
http://dx.doi.org/10.1177/00031348211033542DOI Listing

Publication Analysis

Top Keywords

trauma patients
16
patients severe
12
patients
10
severe hemorrhage
8
trauma centers
8
female trauma
8
teg rotem
8
females longer
8
trauma
6
gender
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: