In this paper, we present experimental studies on newly developed multiplexed chirped tilted fiber Bragg gratings (MCTFBGs) for stimulated Raman scattering (SRS) suppression for high-power fiber laser systems. The MCTFBG device is composed of five continuous segments of chirped tilted fiber Bragg gratings (CTFBGs), which are inscribed into the large-mode-area (LMA, 25/400μm) fibers. The SRS suppression capability of the MCTFBG device has been successfully demonstrated with a master oscillator power amplification (MOPA) fiber laser system at the output level of 3.4 KW. The experimental observation thus indicates the MCTFBG's excellent SRS suppression capability at a very high power level (∼15 dB under >3 kW) and high thermal handling capacity (∼1.48℃/kw). Our work thus provides a key development of essential fiber grating components that can effectively suppress the SRS suppression at a very high power level.
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http://dx.doi.org/10.1364/OE.426979 | DOI Listing |
Nat Methods
January 2025
Department of Electrical and Computer Engineering, Boston University, Boston, MA, USA.
Super-resolution imaging of cell metabolism is hindered by the incompatibility of small metabolites with fluorescent dyes and the limited resolution of imaging mass spectrometry. We present ultrasensitive reweighted visible stimulated Raman scattering (URV-SRS), a label-free vibrational imaging technique for multiplexed nanoscopy of intracellular metabolites. We developed a visible SRS microscope with extensive pulse chirping to improve the detection limit to ~4,000 molecules and introduced a self-supervised multi-agent denoiser to suppress non-independent noise in SRS by over 7.
View Article and Find Full Text PDFJ Biol Rhythms
January 2025
Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado.
Although the sensitivity of the circadian system to the characteristics of light (e.g., biological timing, intensity, duration, spectrum) has been well studied in adults, data in early childhood remain limited.
View Article and Find Full Text PDFPediatr Neurol
December 2024
Department of Surgery, University of Rochester Medical Center, Rochester, New York. Electronic address:
Background: During infant aortic arch reconstruction, traditional electroencephalography (EEG) provides only qualitative data limiting neuromonitoring efficacy. Interhemispheric differences in the alpha:delta ratio (ADR) and suppression ratio (SR) measured using quantitative EEG generate numerical trends that may suggest cerebral ischemia. We hypothesized that the ADR and SR during cardiopulmonary bypass (CPB) would correlate with hemodynamics, and that ADR and SR interhemispheric differences would precede neurological injury from infants requiring aortic arch reconstruction.
View Article and Find Full Text PDFClin Transl Oncol
December 2024
The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
Free Radic Biol Med
November 2024
State Key Laboratory of Biocontrol and School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Provincial Key Laboratory for Aquatic Economic Animals and Guangdong Provincial Engineering Technology Research Centre for Healthy Breeding of Important Economic Fish, Sun Yat-Sen University, Guangzhou, 510275, China. Electronic address:
Scavenger receptors (SRs), a category of pattern recognition receptors primarily expressed on the surface of myeloid cells, play pivotal roles in oxidation response and lipid metabolism. However, current research on Scavenger Receptor class F type II (SRECⅡ) revolves around Van Den Ende-Gupta Syndrome (VDEG), the potential function of SRECII, particularly in regulating lipid metabolism and oxidative stress processes, remains elusive. Herein, we elucidate that SRECII from Epinephelus coioides (EcSRECII) may modulate fatty acid oxidation and oxidative stress levels via interactions with lipoprotein particles.
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