Case: A 39-year-old woman presented with a ganglion cyst in the carpal tunnel simultaneously compressing the right median nerve and the deep palmar branch of the ulnar nerve. During surgery, the soft tissue was exposed under the median nerve and on the deep palmar branch of the ulnar nerve running transversely in the deep area of the carpal tunnel.
Conclusion: Simultaneous compression of the median nerve and deep palmar branch of the ulnar nerve is extremely rare; however, such a pathoanatomical relationship must be considered while examining a patient because these nerves are located close to each other.
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http://dx.doi.org/10.2106/JBJS.CC.20.00692 | DOI Listing |
Alzheimers Dement
December 2024
Laboratory for Molecular Neurobiomarker Research (LaMoN), KU Leuven, Leuven, Belgium.
Background: Synaptic loss is a critical early pathological hallmark of neurodegeneration, in particular in Alzheimer's disease (AD), as evidenced by in vitro as well as in vivo PET studies. To date, it is not clear how blood-based synaptic and AD biomarkers relate to synaptic density in the brains of non-demented elderly, including those diagnosed with depression.
Method: This cross-sectional study included 61 older adults with no history of dementia (age [mean±SD] = 71±6 years, MMSE (median[IQR] = 28[3], 64% female, 38% late-life depression) from the Leuven late-life depression (L3D) study.
Alzheimers Dement
December 2024
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Gothenburg, Sweden.
Background: Synaptic dysfunction is a prominent feature in neurodegenerative disorders, associating with cognition. In contrast to most synaptic proteins assessed in cerebrospinal fluid (CSF), Neuronal pentraxin 2 (NPTX2), essential for synaptic plasticity, exhibits downregulation neurodegenerative disorders through mass spectrometry (MS) methods. While MS-based assays hold promise, their constraints hinder widespread clinical adoption.
View Article and Find Full Text PDFJ Hand Surg Eur Vol
January 2025
Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
This study assessed the effectiveness of adding leukocyte-poor platelet-rich plasma (PRP) during carpal tunnel release surgery for patients with moderate to severe carpal tunnel syndrome. In a randomized controlled trial, 70 patients were assigned to either standard carpal tunnel release (control group) or release with leukocyte-poor PRP applied to the median nerve (PRP group). Primary outcomes were measured using the Boston Carpal Tunnel Questionnaire at 3 months, and secondary outcomes included pain, strength, sensation and electrodiagnostic examinations at multiple time points.
View Article and Find Full Text PDFCannabis
December 2024
Department of Anesthesia, McMaster University.
Objective: People living with chronic pain increasingly use medical cannabis for symptom relief. We conducted a retrospective cohort study examining cannabis for chronic pain relief using anonymous archival data obtained from the medicinal cannabis tracking app, Strainprint®.
Method: We acquired cannabis utilization data from 741 adults with chronic pain and used multilevel modeling to examine the association of age, sex, type of pain (muscle, joint or nerve pain), cannabis formulation (high CBD, balanced CBD:THC, or high THC), route of administration (inhaled or ingested), cannabis use before vs.
JTCVS Open
December 2024
Department of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, WVa.
Objective: To evaluate the healthcare costs associated with unresolved slipping rib syndrome (SRS).
Methods: Data pertaining to patients who underwent operative repair for SRS at our academic institution were analyzed retrospectively. Duration of symptoms, previous management efforts, number of healthcare provider consultations, imaging studies, adjunctive surgical and pain management procedures performed to treat the symptoms, and prior unsuccessful SRS operations were catalogued.
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