A novel and effective method for the synthesis of spirolactones from readily available α-keto acids and 1,3-enynes is developed via a BF·EtO-promoted cascade annulation. This sequential process is conducted at room temperature, and it provides the functionalized spirolactones in good to excellent yield under metal-free conditions.
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| http://dx.doi.org/10.1021/acs.orglett.1c01827 | DOI Listing |
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