HLA-DQB1*03:457 differs from HLA-DQB1*03:02:01:01 by a non-synonymous nucleotide substitution in codon 95, changing valine to glutamic acid.
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http://dx.doi.org/10.1111/tan.14366 | DOI Listing |
Leukemia
December 2024
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, Guangdong, China.
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy and the most common form of non-Hodgkin lymphoma (NHL) that occurs worldwide. To discover risk factors and pathogenesis of DLBCL, we performed the largest GWAS of DLBCL to date in samples of East Asian ancestry, consisting of 2,888 patients with DLBCL and 12,458 controls. The meta-analysis identified three novel loci, rs2233434 on 6p21.
View Article and Find Full Text PDFJ Neurochem
January 2025
Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
To date, several studies have integrated genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data from bulk tissues to identify novel Alzheimer's disease (AD) genetic variants and susceptibility genes. However, there is highly cell-type-specific nature in different bulk eQTL data. Until now, eQTL data from different brain single cells have been reported.
View Article and Find Full Text PDFHLA
December 2024
Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russian Federation.
Four novel HLA alleles HLA-A*02:01:222, -B*07:02:104, -C*07:02:156 and -DQB1*06:03:51 alleles detected during routine next generation sequencing.
View Article and Find Full Text PDFHLA
December 2024
Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain.
Description of the novel HLA-DQA1*05:05:23 and -DQB1*03:562 alleles.
View Article and Find Full Text PDFHLA
December 2024
Histocompatibility and Immunogenetics Laboratory, St. Paul's Hospital, Saskatoon, Saskatchewan, Canada.
The novel allele HLA-DQB1*02:02:01:14 differs from HLA-DQB1*02:02:01:01 by one nucleotide substitution in codon 233 in exon 5.
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