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Characterization of meningitis-causing bacteria, with focus on genomic and pangenomic study of multi-drug resistant Streptococcus pneumoniae from cerebrospinal fluid.
Antonie Van Leeuwenhoek
October 2024
Neuroscience Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Article Synopsis
- Streptococcus pneumoniae is a significant cause of meningitis in underdeveloped countries with low vaccination rates, and this study analyzed 83 suspected meningitis patients in Karachi to identify and sequence the bacteria.
- Out of 83 samples, 33 showed signs of potential meningitis, with 20 confirmed cases of bacterial meningitis, resulting in five isolates of S. pneumoniae being identified, one of which exhibited resistance to multiple antibiotics.
- The whole-genome sequencing of the resistant strain revealed critical genetic factors for antibiotic resistance and indicated a close relation to strains from Hungary and the USA, contributing to our understanding of the prevalence and characteristics of S. pneumoniae in Karachi.
Evaluation of an automated rapid plasma reagin test of serum and cerebrospinal fluid for monitoring neurosyphilis treatment: A case report.
J Infect Chemother
February 2025
Department of Infectious Diseases, Faculty of Medical Sciences, University of Fukui, Japan. Electronic address:
This case report explores the utility of monitoring automated rapid plasma reagin (RPR) test results in both serum and cerebrospinal fluid (CSF) samples from a patient undergoing treatment for neurosyphilis. Syphilis treatment is based on the rapid plasma reagin (RPR) and syphilis treponema antibody levels, and in the case of RPR-positive syphilis, a 1/4 reduction in the RPR value by the manual card test is considered curative. However, it should be noted that when RPR is followed by the manual card test, there may seem to be no reduction when the automated method shows a steady reduction.
View Article and Find Full Text PDF[Molecular biological identification of a case with A223B subtype].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
August 2024
Department of Blood Transfusion, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Objective: To study the molecular basis for a proband with A subtype B of the ABO blood group and explore the influence of amino acid variant on the activity of glycosyltransferase (GT).
Methods: A proband who had presented at the First Affiliated Hospital of Zhengzhou University on July 2, 2020 was selected as the study subject. Serological identification of the ABO blood groups of the proband and her family members were performed by gel card and test tube methods.
Health facility-based prevalence of typhoid fever, typhus and malaria among individuals suspected of acute febrile illnesses in Southwest Region, Ethiopia.
Front Epidemiol
July 2024
School of Medical Laboratory Sciences, Faculty of Health Science, Institute of Health, Jimma University, Jimma, Ethiopia.
Background: Acute febrile illnesses such as typhoid fever, typhus, and malaria are still major causes of hospital admission in many parts of Ethiopia. However, there are substantial gaps in the monitoring systems, which result in a lack of knowledge about the geographic distribution and role of common pathogens, particularly in rural areas. Thus, this study was aimed at assessing the seroprevalence of typhoid fever, typhus, and malaria among suspected acute febrile patients at the MTU Teaching Hospital and Mizan-Aman Health Center, Southwest region of Ethiopia.
View Article and Find Full Text PDFOlfactory Dysfunction as a Marker for Cognitive Impairment in General Paresis of the Insane: A Clinical Study.
Med Sci Monit
July 2024
Geriatric Neuroscience Center, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
BACKGROUND General paresis of the insane (GPI) is characterized by cognitive impairment, neuropsychiatric symptoms, and brain structural abnormalities, mimicking many neuropsychiatric diseases. Olfactory dysfunction has been linked to cognitive decline and neuropsychiatric symptoms in numerous neuropsychiatric diseases. Nevertheless, it remains unclear whether patients with GPI experience olfactory dysfunction and whether olfactory dysfunction is associated with their clinical manifestations.
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