This consensus statement is an update of the 1987 American College of Sports Medicine (ACSM) position stand on the use of anabolic-androgenic steroids (AAS). Substantial data have been collected since the previous position stand, and AAS use patterns have changed significantly. The ACSM acknowledges that lawful and ethical therapeutic use of AAS is now an accepted mainstream treatment for several clinical disorders; however, there is increased recognition that AAS are commonly used illicitly to enhance performance and appearance in several segments of the population, including competitive athletes. The illicit use of AAS by competitive athletes is contrary to the rules and ethics of many sport governing bodies. Thus, the ACSM deplores the illicit use of AAS for athletic and recreational purposes. This consensus statement provides a brief history of AAS use, an update on the science of how we now understand AAS to be working metabolically/biochemically, potential side effects, the prevalence of use among athletes, and the use of AAS in clinical scenarios.
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http://dx.doi.org/10.1249/MSS.0000000000002670 | DOI Listing |
J Environ Manage
December 2024
Faculty of Science and Technology, Norwegian University of Life Sciences, P.O. Box 5003, Aas, 1430, Norway.
Primary sludge can serve as an internal carbon source for denitrification in wastewater treatment plants (WWTPs). This study explores the use of alkaline treatment to produce a fermentation broth from primary sludge, which predominantly contains short-chain volatile fatty acids (VFAs), with acetic acid and propionic acid making up over 65% of the total VFAs. The performance of this fermentation broth as a sole carbon source for denitrification was compared with that of sodium acetate, acetic acid, methanol, and ethanol in both biofilm and activated sludge systems.
View Article and Find Full Text PDFCurr Opin Biotechnol
December 2024
Department of Life Sciences, Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. Electronic address:
The genetic code is a universally conserved mechanism that translates genetic information into proteins, consisting of 64 codons formed by four nucleotide bases. With a few exceptions, the genetic code universally encodes 20 canonical amino acids (AAs) and three stop signals, with many AAs represented by multiple codons. Genetic engineering has expanded this system through approaches like codon reassignment and synthetic base pair introduction, allowing for the incorporation of noncanonical AAs (ncAAs) into proteins, known as genetic code expansion (GCE).
View Article and Find Full Text PDFImportance: This research describes which articles published in Urogynecology are garnering the most attention online. Understanding which articles are having the largest impact in the online community has become increasingly important due to the exponential increase in the use of social media on the internet.
Objective: The Altmetric Attention Score (AAS) is a quantitative and qualitative measure of the articles' online attention in social media and news outlets, blogs, and reference managers.
BMC Cardiovasc Disord
December 2024
Department of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Backgrounds: Due to the high mortality and hospitalization rate in chronic heart failure (HF), it is of great significance to study myocardial nutrition conditions. Amino acids (AAs) are essential nutrient metabolites for cell development and survival. This study aims to investigate the associations and prognostic value of plasma branched-chain amino acid/aromatic amino acid ratio (Fischer's ratio, FR) in patients with left ventricular ejection fraction (LVEF) ≤ 50%.
View Article and Find Full Text PDFToxins (Basel)
December 2024
Research Department for Limnology, University of Innsbruck, Mondseestrasse 9, 5310 Mondsee, Austria.
Recently, the use of click chemistry for localization of chemically modified cyanopeptides has been introduced, i.e., taking advantage of promiscuous adenylation (A) domains in non-ribosomal peptide synthesis (NRPS), allowing for the incorporation of clickable non-natural amino acids (non-AAs) into their peptide products.
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