AI Article Synopsis
- - The study focuses on how HIV infection affects different B cell subsets, particularly the CD27CD38 B cells, which accumulate in individuals recently infected with HIV.
- - Researchers found that these CD27CD38 B cells have a transitional phenotype and can facilitate HIV infection in primary CD4 T cells, suggesting they play a role in the disease's progression.
- - Higher levels of CD27CD38 B cells in early HIV infection correlate with faster disease progression, indicating their potential impact on chronic HIV infection outcomes.
Article Abstract
Although peripheral B cell dysfunction in early HIV infection is established, how B cell subsets are altered by HIV infection is poorly understood. While investigating B cell subsets among individuals recently infected with HIV, we observe an accumulation of CD27CD38 B cells and find that these cells can directly facilitate HIV infection of primary CD4 T cells in vitro. Comprehensive analyses of the phenotype, function, and transcriptome of the CD27CD38 B cell subset is conducted compared with memory and naive B cells. We find that the CD27CD38 B cells exhibit a transitional B cell phenotype and an extremely high turnover rate. Importantly, individuals with higher proportions of CD27CD38 B cells during early HIV infection tend to become rapid progressors in the chronic infection stage. In this study, we identify a peripheral transitional B cell subset that accumulates during early HIV infection and may contribute to disease progression.
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| http://dx.doi.org/10.1016/j.celrep.2021.109344 | DOI Listing |
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