AI Article Synopsis

  • - The study investigates the impact of cadmium exposure on heart metabolism and lipid storage in male Wistar rats, focusing on glucose and fatty acid metabolism.
  • - Results show cadmium significantly decreases insulin levels, affects specific enzyme activities (like pyruvate dehydrogenase), and increases fatty acid, cholesterol, and triglyceride levels in the heart, indicating metabolic disturbance.
  • - The findings suggest that cadmium interferes with how the heart processes glucose and fats, which may lead to decreased efficiency of the heart function in diabetic cardiomyopathy.

Article Abstract

Context: Suppressed glucose metabolism, elevated fatty acid metabolism and lipid deposition within myocardial cells are the key pathological features of diabetic cardiomyopathy. Studies have associated cadmium exposure with metabolic disturbances.

Objective: To examine the effects of cadmium exposure on cardiac glucose homeostasis and lipid accumulation in male Wistar rats.

Methods: Male Wistar rats were treated for 21days as (=5): Control, cadmium chloride Cd5 (5mg/kg, ), cadmium chloride Cd30 (30mg/kg, ).

Results: The fasting serum insulin level in this study decreased significantly. Pyruvate and hexokinase activity reduced significantly in the Cd5 group while no significant change in lactate and glycogen levels. The activity of pyruvate dehydrogenase enzyme significantly increased with an increasing dosage of cadmium. The free fatty acid, total cholesterol and triglyceride levels in the heart increased significantly with increasing dosage of cadmium when compared with the control. Lipoprotein lipase activity in the heart showed no difference in the Cd5 group but a reduction in the activity in the Cd30 group was observed.

Conclusion: This study indicates that cadmium exposure interferes with cardiac substrate handling resulting in impaired glucometabolic regulation and lipid accumulation which could reduce cardiac efficiency.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280890PMC
http://dx.doi.org/10.1080/07853890.2021.1947519DOI Listing

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