AI Article Synopsis
- Many viral infections are on the rise and causing significant global health issues, while drug resistance in viruses is increasing.
- There is an urgent need for effective broad-spectrum antiviral agents to address these challenges, with covalent inhibitors showing promise due to their efficiency and long-lasting effects.
- This chapter reviews the structures and mechanisms of covalent inhibitors targeting various viruses, including SARS-CoV-2 and HIV, and discusses how computer-based studies can aid in their design.
Article Abstract
Nowadays, many viral infections have emerged and are taking a huge toll on human lives globally. Meanwhile, viral resistance to current drugs has drastically increased. Hence, there is a pressing need to design potent broad-spectrum antiviral agents to treat a variety of viral infections and overcome viral resistance. Covalent inhibitors have the potential to achieve both goals owing to their biochemical efficiency, prolonged duration of action, and the capability to inhibit shallow, solvent-exposed substrate-binding domains. In this chapter, we review the structures, activities, and inhibition mechanisms of covalent inhibitors against severe acute respiratory syndrome coronavirus 2, dengue virus, enterovirus, hepatitis C virus, human immunodeficiency virus, and influenza viruses. We also discuss the application of in silico study in covalent inhibitor design.
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| http://dx.doi.org/10.1007/978-981-16-0267-2_11 | DOI Listing |
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