This case illustrates the need to consider SARS-CoV-2 infection as a catalyst for Coombs-negative hemolytic anemia as well as the potential for IVIG to serve as an effective treatment for the condition.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259792 | PMC |
http://dx.doi.org/10.1002/ccr3.4503 | DOI Listing |
Indian J Nephrol
June 2024
Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.
Paroxysmal nocturnal haemoglobinuria (PNH), although a rare type of acquired hemolytic anemia, can be life-threatening if not diagnosed early. Kidney involvement in PNH varies from reversible acute kidney injury to irreversible chronic damage. Here, we report a case of recurrent acute kidney injury in a young male requiring renal replacement support.
View Article and Find Full Text PDFWarm autoimmune hemolytic anemia (WAIHA) occurs due to antibodies active at body temperature that react with antigens on the surface of red blood cells, leading to hemolysis. Antibodies are typically IgG. WAIHA, associated exclusively with IgA antibodies, remains rare.
View Article and Find Full Text PDFSystemic COVID-19 disease is associated with a variety of organ involvement in infected patients. A rarely reported complication is the induction of complement-mediated thrombotic microangiopathy (TMA). TMA is an extremely rare pathological condition that results in thrombosis in capillaries and small arterioles, due to an endothelial injury.
View Article and Find Full Text PDFTurk J Pediatr
May 2024
Department of Pediatric Nephrology, Faculty of Medicine, Mersin University, Mersin, Türkiye.
Background: Hemolytic uremic syndrome (HUS) is a serious cause of acute kidney injury in children. There is a suggestion that coronavirus disease 2019 (COVID-19) may be a trigger for HUS. In this study, we present a pediatric case diagnosed with HUS associated with COVID-19, which progressed to end-stage kidney disease.
View Article and Find Full Text PDFCureus
April 2024
Critical Care Medicine, New York Medical College, Landmark Medical Center, Woonsocket, USA.
COVID-19 infections are known to cause multi-organ complications. Hematological complications like autoimmune hemolytic anemia with a positive direct antiglobulin test (DAT), are commonly encountered. However, Coombs-negative hemolytic anemia is extremely rare.
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