AI Article Synopsis
Article Abstract
This study showed a rare case of Merkel cell carcinoma (MCC) with atypical manifestations accompanied by chronic lymphocytic leukemia of B-cell type that underwent chemotherapy and had poor prognosis. The findings suggest that the physicians should consider MCC when performing diagnosis and assess all possible associated risk factors like neoplasms to achieve good prognosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259794 | PMC |
| http://dx.doi.org/10.1002/ccr3.4498 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Merkel cell carcinoma is a rare neuroendocrine tumor with high mortality. It is well known that clonal integration of the Merkel cell polyomavirus into the dermal precursor cells is a hypothesized pathway in Merkel cell carcinoma pathogenesis. Here, we demonstrate a case of Merkel cell carcinoma (primary origin unknown) presenting with high Merkel cell polyomavirus DNA levels in swabs obtained from normal skin.
View Article and Find Full Text PDFKRT20-/SATB2+/MCPyV+ Sinonasal Merkel Cell Carcinoma: A Detailed Immunohistochemical and In Situ Hybridization Study.
Int J Surg Pathol
January 2025
Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil.
Merkel cell carcinoma (MCC) is an uncommon aggressive neoplasm, usually arising in sun-exposed skin of the head and neck. By immunohistochemistry, KRT20 and MCPyV positivity are found in about 90% and 80% of MCCs, respectively. Noteworthy, viral status in lip/oral cavity MCCs is poorly known.
View Article and Find Full Text PDFHerpesviruses mimic zygotic genome activation to promote viral replication.
Nat Commun
January 2025
Institute of Virology, University Medical Center, and Faculty of Medicine, Albert-Ludwig-University Freiburg, Freiburg, Germany.
Zygotic genome activation (ZGA) is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In humans, ZGA is induced by DUX4, a pioneer factor that drives expression of downstream germline-specific genes and retroelements. Here we show that herpesviruses from all subfamilies, papillomaviruses and Merkel cell polyomavirus actively induce DUX4 expression to promote viral transcription and replication.
View Article and Find Full Text PDFNicotinic Acetylcholine Receptor Expression in Merkel Cell Carcinoma Is Associated With Clinical and Histopathologic Parameters.
J Cutan Pathol
January 2025
Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Background: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy with neuroendocrine differentiation. Several molecular pathways have been implicated in MCC development and multiple cell-of-origin candidates have been proposed, including neural crest cells, which express acetylcholine receptors (AChRs). The role of nicotinic acetylcholine receptors (nAChRs) in MCC has not been explored.
View Article and Find Full Text PDFMerkel cell carcinoma of the dorsal forearm.
JAAD Case Rep
January 2025
Department of Dermatology, Baylor Scott & White Medical Center, Temple, Texas.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!