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Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer. | LitMetric

AI Article Synopsis

  • The study investigates the role of immune biomarkers in the blood of advanced breast cancer patients undergoing treatment, focusing on myeloid derived suppressor cells, regulatory T cells, and activated T lymphocytes.
  • Results show that patients with advanced breast cancer have higher levels of immune suppressive cells compared to healthy women, suggesting a distinct immune profile in cancer.
  • The research indicates that changes in the levels of these immune cells during treatment correlate with clinical outcomes, providing insights for future cancer research and potential therapeutic strategies.

Article Abstract

Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, regulatory T cells, and OX40 + and PD-1 + T lymphocytes counts) in peripheral blood of patients diagnosed with advanced breast cancer were analyzed along of first line antineoplastic therapy. Subsequently, a comparison between groups with clinical benefit versus progression of disease and with a healthy women cohort was executed. Results reflected that patients showed higher basal levels of myeloid derived suppressor cells (35.43, IR = 180.73 vs 17.53, IR = 16.96 cells/μl; p = 0.001) and regulatory T cells (32.05, IR = 29.84 vs 22.61, IR = 13.57 cells/μl; p = 0.001) in comparison with healthy women. Furthermore, an increase in the number of activated T lymphocytes (expressing OX40), a decrease of immune inhibitory cells (MDSCs and Tregs) and inhibited T lymphocytes (expressing PD-1) were observed along the treatment in patients with clinical benefit (p ≤ 0.001). The opposite trend was observed in the case of disease progression. These findings suggest that some critical immune elements can be easily detected and measured in peripheral blood, which open a new opportunity for translational research, as they seem to be correlated with clinical evolution, at least in ABC.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277895PMC
http://dx.doi.org/10.1038/s41598-021-93838-wDOI Listing

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