Nocardia species are opportunistic bacteria that are frequently contagious by inhalation. Recently, Nocardia abscessus has been described as a different species. We report a 54-year-old male who presented with acute pleuritic chest pain, mimicking pulmonary thromboembolism on the 5th day of discharge from the hospital. The patient was receiving immunosuppressive therapy for newly diagnosed atypical anti-glomerular basement membrane disease. Thorax computed tomography revealed a 17x19 mm soft tissue lesion in the lateral segment of the middle lobe of the right lung. After further examinations, a biopsy decision was made and Nocardia abscessus was isolated in the aerobic culture of the aspiration material.
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[Learning from Natural Products: Study on Actinomycetes of the Genus Nocardia].
Yakugaku Zasshi
January 2024
School of Pharmacy at Fukuoka, International University of Health and Welfare.
The genus Nocardia comprises gram-positive bacteria, most of which are pathogenic and cause opportunistic infections of the lungs, skin, and brain in humans. Based on a collaboration study with the Medical Mycology Research Center, Chiba University, we focused on Nocardia actinomycetes as a new natural-product resource. First, by culturing (monoculture) Nocardia in various media, we isolated a new aminocyclitol nabscessin A from Nocardia abscessus IFM10029 and a new γ-lactone inohanalactone from Nocardia inohanaensis IFM0092.
View Article and Find Full Text PDFClinical characteristics of hospitalized patients with Nocardia genus detection by metagenomic next generation sequencing in a tertiary hospital from southern China.
BMC Infect Dis
November 2023
Department of Pulmonary and Critical Care Medicine (PCCM), Fifth Affiliated Hospital of Sun Yat-Sen University, 52 East Meihua Rd, Zhuhai City, 519000, Guangdong Province, China.
Objective: As an opportunistic pathogen, Nocardia often occurring in the immunocompromised hosts. As the unspecifc clinical presentation and low identification rate of the culture dependent methods, Nocardia infection may be under-diagnosis. Recent study have reported physicians could benefit from metagenomic next-generation sequencing (mNGS) in Nocardia diagnosis.
View Article and Find Full Text PDFPhenotypic and genotypic analysis of antimicrobial resistance in Nocardia species.
J Antimicrob Chemother
September 2023
Clinical Microbiology Laboratory, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel.
Article Synopsis
- - The study investigated the antimicrobial resistance and genetic factors of 138 clinical strains of Nocardia species, revealing a variety of species with differing resistance profiles.
- - Nocardia cyriacigeorgica was the most prevalent species, with linezolid being effective against all isolates, while resistance often correlated with specific resistance genes or mutations.
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Design of a multi-epitope vaccine against six Nocardia species based on reverse vaccinology combined with immunoinformatics.
Front Immunol
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Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: genus, a complex group of species classified to be aerobic actinomycete, can lead to severe concurrent infection as well as disseminated infection, typically in immunocompromised patients. With the expansion of the susceptible population, the incidence of Nocardia has been gradually growing, accompanied by increased resistance of the pathogen to existing therapeutics. However, there is no effective vaccine against this pathogen yet.
View Article and Find Full Text PDFMetagenomic next-generation sequencing provides prognostic warning by identifying mixed infections in nocardiosis.
Front Cell Infect Microbiol
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Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
is an opportunistic pathogen that mainly involves immunosuppressed patients and causes a high mortality rate. As an emerging approach to detect infectious pathogens, metagenomic next-generation sequencing (mNGS) was reported in the detection of . However, there is no evidence demonstrating the effect of mNGS on the prognosis of infection.
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