AI Article Synopsis
- Hemolytic uremic syndrome (HUS) is a serious condition causing acute kidney injury in children, and while it mainly affects the kidneys, 20-40% of cases show involvement of other organs, which can lead to more severe disease and higher mortality rates.
- A case is presented involving a 3-year-old boy with HUS who also experienced rhabdomyolysis, a rare occurrence that indicates muscle involvement, which might not be clinically visible but can worsen kidney function and prognosis.
- Early assessment of any extrarenal complications is crucial for effective management and improving outcomes in HUS patients, due to the high risks associated with the acute phase of the syndrome.
Article Abstract
Hemolytic uremic syndrome, a part of thrombotic microangiopathy, is an important cause of acute kidney injury in children. Hemolytic uremic syndrome primarily targets kidney but extrarenal organ involvement is observed in 20-40% of patients. Extra-renal organ involvement in hemolytic uremic syndrome has been associated with greater disease severity and higher mortality. We describe a 3/-year-old boy of hemolytic uremic syndrome with rhabdomyolysis, which is a rare extrarenal manifestation of hemolytic uremic syndrome. Unlike central nervous or gastrointestinal system involvement in hemolytic uremic syndrome which manifests clinically, muscle involvement may not and, if present, may worsen the existing acute kidney injury and may worsen disease prognosis. Considering the high morbidity and mortality in acute phase of hemolytic uremic syndrome, prompt evaluation to know the extent of extrarenal organ involvement at the earliest is important for management and prognosis of these patients.
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| http://dx.doi.org/10.1177/00494755211029166 | DOI Listing |
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