The synthesis of differently substituted 2,3,4-triarylcyclopent-2-en-1-ones from 2-cyclopentenone via sequential functionalization of a novel 2,4-dibromo-3-(4-methoxyphenyl) cyclopent-2-en-1-one intermediate has been developed. The process provides access to selective arylation at C-4 and C-2 with a broader substrates scope, which includes heteroaryl and alkyl substitution at C-2.
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| http://dx.doi.org/10.1021/acs.joc.1c01039 | DOI Listing |
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