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N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson's disease.
Transl Neurodegener
December 2024
Department of Anatomy and Medical Imaging, University of Auckland, 85 Park Road, Grafton, , Auckland, 1142, New Zealand.
Background: Parkinson's disease (PD) and multiple system atrophy (MSA) are classified as α-synucleinopathies and are primarily differentiated by their clinical phenotypes. Delineating these diseases based on their specific α-synuclein (α-Syn) proteoform pathologies is crucial for accurate antemortem biomarker diagnosis. Newly identified α-Syn pathologies in PD raise questions about whether MSA exhibits a similar diversity.
View Article and Find Full Text PDFCLINICAL AND PATHOLOGIC PRESENTATIONS OF YERSINIOSIS IN VARIOUS NONDOMESTIC SPECIES: AN INVESTIGATION OF OUTBREAKS FROM FOUR NORTH AMERICAN ZOOLOGICAL INSTITUTIONS.
J Zoo Wildl Med
December 2024
San Diego Zoo Wildlife Alliance, San Diego, CA 92112, USA.
Yersiniosis due to can be associated with high morbidity and mortality in various species and has been a cosmopolitan management challenge in zoological institutions. This gram-negative, environmental bacterium thrives in cold, wet conditions and poses a risk to zoo species. Outbreaks can be costly and impact conservation efforts through loss of threatened and endangered species.
View Article and Find Full Text PDFOlfactory function is reduced in a subset of former elite American football players with traumatic encephalopathy syndrome.
Chem Senses
January 2024
Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
Former American football players are at risk for developing traumatic encephalopathy syndrome (TES), the clinical disorder associated with neuropathologically diagnosed chronic traumatic encephalopathy (CTE). The objective of this study was to determine whether hyposmia is present in traumatic encephalopathy syndrome. The study included 119 former professional American football players, 60 former college football players, and 58 same-age asymptomatic unexposed men from the DIAGNOSE CTE Research Project.
View Article and Find Full Text PDFMetastasizing dysgerminoma in an inland bearded dragon (Pogona vitticeps).
BMC Vet Res
December 2024
Clinical Unit for Diagnostic Imaging, University of Veterinary Medicine, Vienna, Austria.
Background: Malignant dysgerminomas are infrequently reported ovarian neoplasms in animals, especially in exotic pets (non-traditional companion animals [NTCAs]). In the few published case reports on reptilian species, examples are primarily postmortem without antemortem (clinical) assessment.
Patient Presentation: An adult, 13-year-old, spayed female inland bearded dragon (Pogona vitticeps) presented with lethargy, a right-sided head tilt, unilateral exophthalmos and ventrotemporal strabismus on the right eye.
Dental profiling in the archaeological sample of the Illyrian population in Southern Dalmatia, Croatia.
Homo
November 2024
University of Zagreb, School of Dental Medicine, Department of Dental Anthropology, Zagreb, Croatia.
Dental profiling is the process of analyzing teeth to identify a victim or skeletal remains when no antemortem data are available. Using dental profiling techniques, we can determine the age, sex, and population of the individual and gather data about their socio-economic status, personal habits, oral and systemic health, occupation, nutrition, family relationships, and psychological characteristics. The research aims to gain insights into the diet, health, socio-economic status, and demography of the Late Iron Age inhabitants of Illyrian origin who lived on the Croatian island of Korcula.
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