A new efficient synthesis of polysubstituted pyrazin-2(1)-ones via the sequential Ugi/Staudinger/aza-Wittig/isomerization reaction has been developed. The four-component Ugi reactions of arylglyoxals , primary amines , α-azidovinyl acids , and isocyanides produced the azides , which were treated with triphenylphosphine to give pyrazin-2(1)-ones in good yields through domino Staudinger/aza-Wittig/isomerization reactions.
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| http://dx.doi.org/10.1021/acs.joc.1c00735 | DOI Listing |
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