Background: Blood products are often a life-saving intervention for both traumatic and medical indications. The United States Indo-Pacific Command (INDOPACOM) is the largest Geographic Combat Command (GCC). Procurement of blood products that meet the US military healthcare standards throughout this region is challenging. Yet, the frequency to which this life-saving intervention is administered remains unclear. We seek to describe blood product administration throughout INDOPACOM.
Methods: This is a secondary analysis of a previously described dataset from the US Transportation Command (TRANSCOM) Regulating Command and Control and Evacuation System (TRAC2ES) from 2008 to 2018.
Results: Between 2008 and 2018, there were 4,217 cases in TRAC2ES originating within INDOPACOM, of which 173 (4%) cases involved blood product transfusion. The largest percentage for patients receiving a blood transfusion was 19-29 years old (29%), followed by patients under a year (21%). Most (66%) of the patients classified as male. Almost half of the patients (49%) were dependents of members of service in parallel with the young patient ages. Anemia (23%) and trauma (20%) , mostly non-combat related, were the largest proportions of indications. The common blood product used was packed red cells (72%) followed by fresh frozen plasma (16%).
Conclusions: Blood products were administered to nearly 1 out of every 25 patients transported within INDOPACOM, which highlights the need for reliable methods for obtaining and maintaining blood products. Given INDOPACOM's vast area of responsibility and possibility for a peer-to-peer war, finding optimal methods to transport and store blood and blood products is imperative.
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Obstet Gynecol
January 2025
Division of Maternal-Fetal Medicine, Department of Obstetrics Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas.
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From the Department of Surgery, University of Cincinnati, Cincinnati, Ohio.
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February 2025
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY.
A segment of people with HIV on effective antiretroviral therapy (ART) continue to experience poor immune recovery, leaving them at heightened risk of non-AIDS-defining events (NAEs). The production of anti-CD4 IgG autoreactive antibodies is suggested as one contributing mechanism to these complications. Here, we found that plasma anti-CD4 levels do not discriminate immunological responders from nonresponders nor predict the occurrence of NAEs, suggesting it is unlikely a contributing immunopathological factor associated with these complications.
View Article and Find Full Text PDFBioconjug Chem
January 2025
Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Nanobodies play an increasingly prominent role in cancer imaging and therapy. However, their efficacy is often constrained by inadequate tumor penetration and rapid clearance from the bloodstream, particularly in brain tumors due to the intractable blood-brain barrier (BBB). Glycosylation is a favorable strategy for modulating the biological functions of nanobodies, including permeability and pharmacokinetics, but it also leads to heterogeneous glycan structures, which affect the targeting ability, stability, and quality of nanobodies.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Engineering (FOE), Multimedia University (MMU), Cyberjaya, Selangor, Malaysia.
Cancer and its diverse variations pose one of the most significant threats to human health and well-being. One of the most aggressive forms is blood cancer, originating from bone marrow cells and disrupting the production of normal blood cells. The incidence of blood cancer is steadily increasing, driven by both genetic and environmental factors.
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