AI Article Synopsis
- Recent studies suggest that rotavirus vaccination might influence the prevalence of type 1 diabetes (T1D) in children under 5 years old in Israel.
- Data on insulin purchases from health organizations revealed a significant increase in T1D diagnoses before the vaccination program, showing a 50% increase in cases from 2002-2007.
- After the introduction of free rotavirus vaccinations from 2011-2018, diagnoses of T1D in young children decreased by 3.8%, indicating a potential link between the vaccination and a reduction in T1D prevalence.
Article Abstract
Background: Recent studies showed that rotavirus vaccination may affect the prevalence of type 1 diabetes (T1D). The aim of the study was to determine the prevalence of early childhood (<5 years) T1D before and during the introduction of rotavirus vaccination in Israel by syndromic surveillance.
Methods: Data on insulin purchases reported by Israel's four Health Maintenance Organizations (HMOs) were retrieved from the National Program for Quality Indicators in Community Healthcare.
Results: During the prevaccination years (2002-2007), a steady increase in insulin purchases was reported in the young (<5 years). The period percent change (PC) of children <5 years old diagnosed with T1D inferred from purchased insulin prescriptions increased by 50.0%, and the annual percent change (APC) increased by 10.0% (p = 0.01). During the period of free, universal Rotavirus vaccination (2011-2018), the PC for T1D diagnoses among children <5 years of age decreased by 3.8% with an APC of -2.5% (p = 0.14). There was a significant difference (p = 0.002) between the increasing trend in insulin use before vaccination versus the decreasing trend after vaccination.
Conclusion: Rotavirus vaccination correlated with attenuation of the increasing rate in the prevalence of T1D in <5-year-old children in Israel.
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| http://dx.doi.org/10.1097/INF.0000000000003148 | DOI Listing |
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