A class of pyrimidine thioglycoside analogs () were synthesized from a reaction of 2-cyano-3,3-dimercapto--arylacrylamide () and thiourea to produce the corresponding 4-amino-2-mercapto--arylpyrimidine-5-carboxamide derivatives (), and stirring of compounds () with peracylated α-d-- and galacto-pyranosyl bromides () in DMF-sodium hydride gave the corresponding pyrimidine thioglycosides () Deacetylation of the pyrimidine thioglycosides via a reaction with dry NH/MeOH gave the corresponding free pyrimidine thioglycosides () The compounds have been characterized by C NMR, H NMR, and IR. Pharmacological evaluation of compounds , , and in vitro against SARS-COV-2 and Avian Influenza H5N1 virus strains revealed that some compounds possess interesting activity.
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| http://dx.doi.org/10.1021/acsomega.1c01501 | DOI Listing |
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