Cefiderocol Pharmacokinetics in a Patient Receiving Continuous Venovenous Hemodiafiltration.

Open Forum Infect Dis

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.

Published: July 2021

AI Article Synopsis

  • Antimicrobial dosing is challenging for patients on continuous renal replacement therapy (CRRT).
  • This case discusses a patient treated with cefiderocol for multidrug-resistant pneumonia and bacteremia, receiving 2 g every 8 hours as a 3-hour infusion during CRRT.
  • The article outlines the patient’s clinical progress and the pharmacokinetics of cefiderocol in their treatment.

Article Abstract

Antimicrobial dosing in patients receiving continuous renal replacement therapy is a continued clinical challenge. We describe a case of a patient receiving cefiderocol 2 g intravenously every 8 hours as a 3-hour infusion for a multidrug-resistant pneumonia and bacteremia while undergoing continuous venovenous hemodiafiltration. The clinical course and cefiderocol pharmacokinetics are described.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266675PMC
http://dx.doi.org/10.1093/ofid/ofab252DOI Listing

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