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Suppresses Tumor Progression by Inhibiting the PI3K/AKT Signaling Pathway in Prostate Cancer. | LitMetric
Background : SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily C member 1 () protein is a potential tumor suppressor in various cancers. However, its role in prostate cancer (PCa) remains controversial. The aim of this study was to determine the biological function of in PCa and explore the underlying regulatory mechanisms.Methods : The expression of was validated in PCa tissues by immunohistochemistry. Meanwhile, function experiments were used to evaluate the regulatory role on cell proliferation and metastasis in PCa cells with depletion both and . The expression levels of relevant proteins were detected by Western blotting.Results : Our finding showed that was significantly downregulated in prostate adenocarcinoma, with a higher Gleason score (GS) than that in low GS. The decreased expression of was significantly correlated with a higher GS and poor prognosis. Additionally, we found that silencing of dramatically accelerated cell proliferation by promoting cell cycle progression and enhancing cell migration by inducing epithelial mesenchymal transition (EMT). Furthermore, depletion of facilitated PCa xenograft growth and lung metastasis in murine models. Mechanistically, the loss of activated the pathway in PCa cells.Conclusion : suppresses PCa cell proliferation and metastasis the signaling pathway and is a novel therapeutic target.
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