A woman in her 40s, previously diagnosed with ulcerative colitis (UC), presented with anterior chest pain. A CT scan of her chest and skin examination showed no abnormal findings. She was initially managed with antibacterial agents, but her chest pain worsened, she developed a fever, and there was an overall deterioration of her general condition. A repeat CT scan found abscesses on the anterior surface of her sternum and gluteal region, and colonoscopy found worsening UC lesions. Her multiple subcutaneous abscesses were aseptic, and she was diagnosed with pyoderma gangrenosum (PG), an extraintestinal manifestation of UC. Steroid treatment was initiated and her overall condition as well as her subcutaneous abscesses improved rapidly. There are only a few case reports of PG without skin manifestation but only subcutaneous aseptic abscesses. However, subcutaneous abscesses may progress to PG with skin ulcers if initial treatment is delayed. Even with non-specific clinical features, prompt diagnosis of relapsed UC with potential extraintestinal manifestations must be considered. This is a rare case and aims to highlight the importance of early diagnosis and treatment of PG, which is an extraintestinal manifestation of relapsed UC.
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http://dx.doi.org/10.11405/nisshoshi.118.671 | DOI Listing |
NPJ Biofilms Microbiomes
January 2025
Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Chronic infections represent a significant global health and economic challenge. Biofilms, which are bacterial communities encased in an extracellular polysaccharide matrix, contribute to approximately 80% of these infections. In particular, pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus are frequently co-isolated from the sputum of patients with cystic fibrosis and are commonly found in chronic wound infections.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
: Community-acquired methicillin-resistant (CA-MRSA) greatly complicates the treatment of skin and soft tissue infections (SSTI). It was previously found that subcutaneous (SQ) treatment with the mononuclear phagocyte (MP)-selective activator complements peptide-derived immunostimulant-02 (CPDI-02; formerly EP67) and increases prophylaxis of outbred CD-1 mice against SQ infection with CA-MRSA. Here, we determined if treatment with CPDI-02 also increases curative protection.
View Article and Find Full Text PDFCureus
December 2024
Department of Ear, Nose, Throat (ENT), Nalanda Medical College and Hospital, Patna, IND.
Phaeohyphomycosis is a fungal infection caused by dematiaceous fungi that presents as a superficial, cutaneous, subcutaneous, or systemic infection. Subcutaneous phaeohyphomycosis is the most common manifestation and presents as a subcutaneous nodule or cystic lesions and abscesses. It usually results from traumatic implantation of the saprophytic fungus from soil and vegetative matter; therefore, the commonest sites of infection are the extremities.
View Article and Find Full Text PDFAcad Radiol
January 2025
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, PR China (M.W., Y.L., D.Z., N.F., Y.W., M.L., H.Z.).
Rationale And Objectives: To summarize the clinical features and ultrasonic characteristics of patients with cystic neutrophilic granulomatous mastitis (CNGM), and to enhance the understanding of CNGM in clinical practice.
Materials And Methods: This study retrospectively analyzed the demographic data, clinical symptoms, and ultrasonic characteristics of 141 patients diagnosed with CNGM through pathological examination. This study was approved by the Medical Ethical Committee of Beijing Hospital of Traditional Chinese Medicine (2023BL02-054-01).
Adv Sci (Weinh)
December 2024
Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Mild hyperthermia therapy has garnered interest as an adjunctive treatment for bone repair. However, its optimal timing, duration, and underlying mechanisms remain unclear. In this study, how mild hyperthermia supports bone repair during the early stages is assesed.
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