REMODELING OF THE RAT DUODENAL WALL UNDER THE EFFECT OF COMPLEX FOOD ADDITIVES OF MONOSODIUM GLUTAMATE, SODIUM NITRITE AND PONCEAU 4R.

The purpose of the study was to establish the dynamics of changes in morphometric parameters of the structural components of the rats' duodenal wall with long-term use of a complex of food additives: sodium nitrite, sodium glutamate and Ponceau 4R. The work was performed on 84 adult nonlinear male rats, which were given to drink 10% sodium nitrite solution, sodium glutamate was administered at a dose of 20 mg/kg in 0.5 ml of distilled water, Ponceau 4R - at a dose of 5 mg/kg in 0.5 ml distilled water 1 time per day orally. Thus, the use of a complex of dietary additives of sodium nitrite, sodium glutamate and Ponceau 4R led to changes in the morphometric parameters of all structural components of the rats' duodenal wall. This reaction is aimed at neutralizing the alterative factor and restoring the morphofunctional state of the duodenum. By the end of the observation, complete recovery of structural components was not established due to the predominance of constant negative influence of the stimulus with the occurrence of dystophic-destructive changes.