[RESULTS OF BIOCHEMICAL AND HISTOLOGICAL RESEARCH IN THE RESTORATION OF BONE DEFECTS WITH THE HELP OF MULTIPOTENT MESENCHYMAL STROMAL CELLS OF ADIPOSE TISSUE].

The aim of our study was to investigate the effectiveness of osteoplastic material based on MMSC - AT for the restoration of bone defects. To study the processes of bone remodeling, in the replacement of bone defects after tooth extraction, patients were divided into three groups. Group A - 26 patients where used "Kolapan-L" to fill the bone defect; group B - 28 patients where for augmentation used osteoplastic composition "Kolopan-L" + MMSC-AT + PRP; group C - 25 patients in whom the healing of the bone defect occurred under a blood clot. In the patients group B, after 1 year of observation, the activity of acid phosphatase was 13,35% p> 0.05 and 33,40%, p>0,05, p1<0.05 below the increase in alkaline phosphatase by 8,84, p> 0,05, and 15,35%, p>0,05 relative to similar data in groups A and C. The index of bone mineralization in patients of group B was 8,84% and 19,74% higher than in the operated groups A and C, respectively p, p1>0,05, p2<0,05. When conducting histological examination of bone biopsies after 6 months of observation, in patients of group B, the obtained trepan biopsies had the structure of bone tissue: bone marrow spaces and sometimes small particles of osteoplastic material were determined between trabeculae. Therefore, based on the results of the study, it is safe to say that our proposed osteoplastic composition based on MMSC - AT is a good alternative to traditional osteoplastic materials for use in modern dentistry.