Biochemical properties of fission yeast homologous recombination enzymes.

Curr Opin Genet Dev

Institute of Innovative Research, Tokyo Institute of Technology, Kanagawa, Japan; School of Life Science and Technology, Tokyo Institute of Technology, Kanagawa, Japan. Electronic address:

Published: December 2021

Homologous recombination (HR) is a universal phenomenon conserved from viruses to humans. The mechanisms of HR are essentially the same in humans and simple unicellular eukaryotes like yeast. Two highly diverged yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe, have proven exceptionally useful in understanding the fundamental mechanisms of eukaryotic HR by serving as a source for unique biological insights and also complementing each other. Here, we will review the features of S. pombe HR mechanisms in comparison to S. cerevisiae and other model organisms. Particular emphasis will be put on the biochemical characterization of HR mechanisms uncovered using S. pombe proteins.

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http://dx.doi.org/10.1016/j.gde.2021.06.006DOI Listing

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