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AUCs and 123s: a critical appraisal of vancomycin therapeutic drug monitoring in paediatrics-authors' response.
J Antimicrob Chemother
August 2021
Department of Pharmacy, Mount Sinai Hospital, Toronto, ON, Canada.
Comment on: AUCs and 123s: a critical appraisal of vancomycin therapeutic drug monitoring in paediatrics.
J Antimicrob Chemother
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Department of Pharmacy Practice, Midwestern University College of Pharmacy, Downers Grove, IL, USA.
AUCs and 123s: a critical appraisal of vancomycin therapeutic drug monitoring in paediatrics.
J Antimicrob Chemother
August 2021
Pharmacy Services, Alberta Health Services, Calgary, AB, Canada.
The revised vancomycin guidelines recommend implementing AUC24-based therapeutic drug monitoring (TDM) using Bayesian methods in both adults and paediatrics. The motivation for this change was accumulating evidence showing aggressive dosing to achieve high troughs, as recommended in the first guidelines for adults and extrapolated to paediatrics, is associated with increased nephrotoxicity without improving clinical outcomes. AUC24-based TDM requires substantial resources that may need to be diverted from other valuable interventions.
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