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Missing the forest-plot for the trees.
Diabetologia
April 2023
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Systematic reviews and meta-analyses are methods increasingly used in biomedical research since their introduction in the 1970s. They serve to replace other non-systematic and cherry-picked narrative reviews, which are highly variable in their approach, structure and content. Their increase in popularity parallels the increase in overall scientific output, and when properly conducted, systematic reviews can contribute highly impactful summaries of a fast-growing evidence base.
View Article and Find Full Text PDFCherry-Picked or Properly Chosen? CABG for Acute Myocardial Infarction.
Cardiovasc Revasc Med
October 2021
Interventional Cath Lab, Sanger Heart & Vascular Institute, Atrium Health, 100 Medical Park Drive, Suite 210, Concord, NC 28025, United States of America. Electronic address:
Statistical learning and selective inference.
Proc Natl Acad Sci U S A
June 2015
Department of Health Research & Policy and Department of Statistics, Stanford University, Stanford, CA 94305
We describe the problem of "selective inference." This addresses the following challenge: Having mined a set of data to find potential associations, how do we properly assess the strength of these associations? The fact that we have "cherry-picked"--searched for the strongest associations--means that we must set a higher bar for declaring significant the associations that we see. This challenge becomes more important in the era of big data and complex statistical modeling.
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