A dosimetric calibration of three types of radiochromic films (GafChromic HD-V2, MD-V3, and EBT3) was carried out for absorbed doses (D) ranging up to 100 kGy using a 130 TBq Co60 γ-ray source. The optical densities (ODs) of the irradiated films were acquired with the transmission-mode flatbed film scanner EPSON GT-X980. The calibration data were cross-checked using the 20-MeV proton beam from the azimuthally varying field cyclotron at the Research Center for Nuclear Physics in Osaka University. These experimental results not only present the measurable dose ranges of the films depending on the readout wavelength, but also show consistency with our hypothesis that the OD response curve [log(OD)-log(D) curve] is determined by the volumetric average of the absorption dose and does not strongly depend on the type of radiation for the excitation.
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http://dx.doi.org/10.1063/5.0043628 | DOI Listing |
Med Phys
January 2025
Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, NKI-AvL, Amsterdam, Netherlands.
Photodynamic therapy (PDT) is a treatment modality clinically approved for several oncologic indications, including esophageal and endobronchial cancers, precancerous conditions including Barrett's esophagus and actinic keratosis, and benign conditions like age-related macular degeneration. While it is currently clinically underused, PDT is an area of significant research interest. Because PDT relies on the absorption of light energy by intrinsic or administered absorbers, the dosimetric quantity of interest is the absorbed energy per unit mass of tissue, proportional to the fluence rate of light in tissue.
View Article and Find Full Text PDFFront Oncol
December 2024
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Oral Oncol
December 2024
Radiation Medicine Program, Princess Margaret Cancer Centre, M5G 2M9, Toronto, Ontario, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, M5G 2M9 Toronto, Ontario. Electronic address:
Objectives: This study aimed to develop a prediction model for feeding tube dependence in a large homogenous cohort of HPV-associated oropharyngeal squamous cell carcinoma (HPV + OPSCC) patients receiving chemoradiotherapy (CRT). We further aimed to externally validate three previously published feeding tube prediction models on this cohort.
Materials And Methods: p16-confirmed HPV + OPSCC patients treated with definitive CRT at a tertiary cancer centre between April 2017 and February 2022 were identified.
Int J Gen Med
December 2024
Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.
Purpose: To investigate risk factors for esophageal fistula in esophageal squamous cell cancer (ESCC) patients who treated with volumetric modulated arc therapy (VMAT).
Patients And Methods: A retrospective analysis was performed on 171 ESCC patients treated with VMAT at Hefei Cancer Hospital, Chinese Academy of Sciences, from February 2017 to February 2021. Clinical and dosimetric parameters, including age, gender, feeding channel, tumor location, T stage, ulcerative tumor, were recorded.
Front Oncol
December 2024
Department of Radiology, Huadong Hospital, Fudan University, Shanghai, China.
Background: This study aimed to develop and validate a multiregional radiomic-based composite model to predict symptomatic radiation pneumonitis (SRP) in non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT).
Materials And Methods: 189 patients from two institutions were allocated into training, internal validation and external testing cohorts. The associations between the SRP and clinic-dosimetric factors were analyzed using univariate and multivariate regression.
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