AI Article Synopsis
- The study aimed to determine if ultrasound-guided intrauterine insemination (IUI) was more effective than classical IUI in improving pregnancy rates.
- A systematic review of seven randomized clinical trials with 1338 patients revealed that ultrasound-guided IUI significantly increased clinical pregnancy rates, while showing no major differences in miscarriage or live birth rates between the two methods.
- Additionally, ultrasound-guided IUI significantly reduced reported difficulties during the procedure and was found to have high-quality evidence supporting its use.
Article Abstract
Objective: There is a great controversy regarding the benefits of ultrasound-guided intrauterine insemination (IUI) in improving pregnancy rates. Thus, we aimed to compare ultrasound-guided IUI versus classical IUI regarding the pregnancy rates improvement.
Methods: A systematic search was done in Cochrane Library, PubMed, ISI web of science, and Scopus during June 2021. We selected randomized clinical trials (RCTs) that compared ultrasound-guided IUI versus classical IUI in different pregnancy outcomes. We extracted the available data from included studies and pooled them in a meta-analysis model using RevMan software. Our primary outcome was clinical pregnancy rate. Our secondary outcomes were miscarriage, live birth rates, and incidence of difficulty reported during the procedure. The overall quality of evidence was assessed through GRADEpro GDT software.
Results: Seven RCTs met our inclusion criteria with a total number of 1338 patients. We found that ultrasound-guided IUI significantly improved the clinical pregnancy rate when compared to the classical group (RR = 1.33, 95% CI [1.05, 1.68], p = 0.02). However, there were no significant differences between both groups in terms of miscarriage and live birth rates. Ultrasound-guided IUI significantly reduced the incidence of difficulty reported during the procedure (RR = 0.42, 95% CI [0.21, 0.84], p = 0.01). The GRADEpro GDT tool showed high quality of evidence for the evaluated outcomes.
Conclusions: There is evidence of high quality that ultrasound-guided IUI improves the pregnancy rate and reduces the incidence of difficulty reported during the procedure.
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| http://dx.doi.org/10.1016/j.ejogrb.2021.06.039 | DOI Listing |
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